THE INFLUENCE OF JIAOGULAN EXTRACT ON PLATELET AGGREGATION AND ARACHIDONATE METABOLISM IN RABBITS
Li Lin & Jin Youyu (Dept. of Pharmacology, Capital Institute of Medicine, Beijing)
jiaogulan ( Gynostemma pentaphyllum) extract (0.25~2g/L. final concentration) obviously inhibited the platelet aggregation TXB2 release induced by arachidonic acid ( AA ) in vitro, and the ID50 of inhibiting TXB2 release was 0.28g/L. With the dose of 35mg/kg i. v. , it evidently inhibited platelet aggregation at 10 20 min after injection, and also markedly decreased TXB2 released by platelets during 10~40 min after injection, especialy within 20 min. Jiaogulan extract (0.25~4g/L) did not influence 6-keto-PGF1α release of aorta thoracalis of rabbits in vitro. Enzyme immunoassay was used to measure the content of TXB2 6-keto-PGF1α in the experiments. The above results suggest that Jiaogulan extract may decrease TXA2/PGI2 ratio.