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《Chinese Pharmacological Bulletin》 1990-01
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EFFECT OF PANAXATRIOL SAPONIN ( PTS ) ON HUMAN LYMPHOKINE PRODUCTION AND ITS CHARACTERISTICS

Tian Zhigang & Yang Guizhen (Dept. of Immunology, Bethune University of Medical Sciences, Changchun, 130021)  
Under stimulation of PHA,PHA + TPA,or PHA + PTS the time ke-netics of DNA,RNA,protein synthesis and lymphokine secretion by human lymph node cell expressed different responses. The PTS did not increase the DNA and RNA synthesis, but increased the protein synthesis ( 60% ) . TPA increased the RNA synthesis ( 18% ) , therefor increased the protein synthesis ( 40% ) . Both of TPA and PTS increased the production of 5 kinds of lymphokines (IL-1 , IL-2 , IL-3, BCGF, TFNr). We infer that PTS and TPA increase the lymphokine production through different gene regulation. TPA Promotes the translation of lymphokine mRNA。
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