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《Chinese Pharmacological Bulletin》 1991-02
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EFFECTS OF L-THP ON HEMODYNAMICS IN ANAESTHETIZED RATS

Wu Shaoguang,Li Xiaolan, Ren Shilan,Zhao Guoju ( Dept. of Pharmacology, Yunyang Medical College of Tongji Medical University, Shiyan 442000)  
Hemodynamic study of L-THP in anaesthetized rats showed that 6 mg/kg iv decreased only blood pressure (BP) significantly, and decreased left ventricular pressure ( LVP ) temporarily. At the dose of 18 mg/kg, L-THP lowered the BP, LVP, ± ( dP/dt ) max, ( dP/dt ) P-1 and HR. But the degrees o?diminutions of BP were greater than that of cardiac contractility. The inhibitory percentage of L-THP on DAP was greater than that of SAP. In addition, the extent of decrease of DAP was shown dose dependently. The results suggest that L-THP reduces the peripheral vessel resistance, and it inhibits the cardiac contractibility in high dosage.
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