The studies on pharmacokinetics of paeoniflorin in rabbits and rats
CHEN Guang -Liang. CHEN Chong -Hong, XU Shu -Yu (Institute of Clmical Pharmacology, Ahhui Medical University, Heifei 230032)
After iv 25mg · kg-1 paeoniflorin (PF)in rabbits, the concentration-time curves of the PF were shown to fit an two compartment model. The pharmacokinetic parameters were as follows; T1/2α = 5. 93 min. T1/2β = 66. 02 min. Vb = 5l6. 8 ml · kg-1, CL=6. I I ml · kg-1 · min. The bioavail- ability of PF after ig 250mg · kg-1 in rabbits was F=7. 24 ± 4. 15%. Tmax=77. 42 min. Cmax = 21. 57mg · L-1. After ig 550mg · kg-1 PF. about 10. 6 1 % . 1. 08% of the dose was recovered from the rat feccs. urine respectively within 24h. After iv 55mg · kg-1 PF.about 8. 64% of the dose was recovered from the rat bile within 7h. The metabolism of PF was studied in isolated perfused rat liver, the PF concentrations in Krebs -Henseleit solution had little changed during 90 min by recirculating per-fusion.