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《Chinese Pharmacological Bulletin》 1993-06
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Protective effects of total glucosides of paeony on experimental hepatitis

DAI Li-Ming, CHEN Xue-Guang, XU Shu-Yun (Dept Of Pharmacology, Anhui Medical University, Hefei, 230032)  
The protective effects of total glucosides of paeony (TGP) on eoperimental hepatitis were studied in mice. The elevation of SGPT and the decrese of serum protein and hepatic glycogen contents in D-Galactosamine or CCl4-induced hepatitis were significantly improved by pretreatment with TGP (10, 20mg · kg-1d-1×7d,ip). It also remarkably diminished the hepato-cellular degeneration and necrosis induced by D-Galactosamine or CCI4. Moreover, ultrastructural studies showed that TGP markedly restored the structures of mitochondria, lysosome and endoplasma reticulum of hepatocvtes injured by D-Galactosamine. These results indicate that TGP has obviously protective effects on acute hepatitis. The mechanisms of its actions remain to be furthes studied.
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Chinese Journal Full-text Database 10 Hits
1 CHEN Xiang qing,WANG qin mao,FANG Hua wu,SU Cui mei (Dept. Of Pharmacy, Anhui Provincial Hospital,Anhui Hefei 230001,China);PROTECTIVE EFFECTS OF TOTAL GLUCOSIDES OF PAEONY AND EXTRACT FROM ANGELICA SINENSIS ON EXPERIMENTAL HEPATITIS[J];Journal of Anhui Traditional Chinese Medical College;2002-03
2 CHEN Xiang-qing,WANG Qin-mao,FANG Hua-wu,et al (Dept.Of Pharmacy,Anhui Provinical Hospital,Anhui Hefei 230001,China);PROTECTIVE EFFECTS OF TOTAL GLUCOSIDES OF PAEONY AND EXTCACT FROM ANGELICA SINENSIS ON EXPERIMENTAL IMMUNOLOGICAL LIVER INJURY[J];Journal of Chengde Medical College;2004-01
3 XIONG Jin-he,TANG Xue-mei.Department of Rheumatology,Suining People's Hospital,Suining Sichuan 629000,China;Clinical Observation of Total Glycosides of Wite Paeony Combined with Methotrexate and Sulfasalazine on the Treatment of Ankylosing Spondylitis[J];West China Medical Journal;2009-04
4 XIAO Kun~* (Department of Clinical Medicine,Peking Union Medical College,Beijing 100730,China);Application of Total Glucosides of Peony in Autoimmune Diseases[J];Chinese Journal of Allergy and Clinical Immunology;2008-01
5 ZHOU Qiang,LI Zhan guo (Department of Rheumatology and Immunology, People's Hospital, Peking University, Beijing 100044, China);Pharmaceutical effects of total glucosides of peony and its application in autoimmune disease[J];Chinese Journal of New Drugs and Clinical Remedies;2003-11
6 WANG Hua,WEI Wei, YUE Li,WANG Ni ping ,GUI Shuang ying,WU Li,SUN Wu yi,XU Shu yun (Institute of Clinical Pharmacology , Anhui Medical University, Hefei 230032,China);Protective effect of total glucosides of paeony on immunological liver injury in mice induced by Bacillus Calmette-Guerin plus lipopolysaccharide[J];Chinese Pharmacological Bulletin;2004-08
7 Zhang Anping, Ni Feizhou, Sheng Yuxian et al;Studies on pharmacodynamics of selenium yeast[J];Acta Universitis Medicinalis Nahui;1996-05
8 Li Xiang,Liu Hao,Lu Jingtao,et al(Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory ofAnti-inflammatory and Immunopharmacology of Education Ministry,Anhui EngineeringTechnology Research Center of Anti-inflammatory and Immunodrugs,Hefei 230032);The effect of kupffer cells on the proliferation of hepatic stellate cells isolated from rats with immunological liver injury and the role of paeoniflorin[J];Acta Universitatis Medicinalis Anhui;2008-06
9 HE Qiu-bo,LI Hong-wen,DONG Hui-ting(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China);Efficacy Observation of Acitretin Combined with TGP in the Treatment of Psoriasis Vulgaris[J];China Pharmacy;2010-16
10 CHEN Yong. Zhejiang Provincial Ninbo City 1st Hospital Rheumatism Department, Ninbo(315010) China;Clinical Curative Effect Investigation on Integrated Total Glucosides of Peony and Sulfasalazine in Treating Ankylosing Spondylitis[J];Zhejiang Journal of Integrated Traditional Chinese and Western Medicine;2004-10
Chinese Journal Full-text Database 1 Hits
1 Wang Yongxiang ,Wang Weiqun & Huang Jiping et al (Dept. of Phar., Anhui Medical University , Hefei);THE PROTECTIVE EFFECT OF TGPs ON ACUTE LIVER INJURY INDUCED BY CARBON TETRACHLORIDE IN MICE[J];Chinese Pharmacological Bulletin;1988-06
Chinese Journal Full-text Database 8 Hits
1 Fan S,Zuo JP,Yi C,Peng GP,Yang H,Shi GR,Rao LQ. 1College of Bioscience and Biotechnology,Hunan Agricultural University,Changsha 410128,Hunan Province,China; 2Hunan Environment-Biological Polytechnic,Hengyang 421005,Hunan Province,China;Extraction and primary isolation of hepatoprotective active ingredients on Phyllanthus urinaria L.and carbon tetrachloride-injured models of primary hepatocytes in rats[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2007-38
2 CHEN Guang -Liang. CHEN Chong -Hong, XU Shu -Yu (Institute of Clmical Pharmacology, Ahhui Medical University, Heifei 230032);The studies on pharmacokinetics of paeoniflorin in rabbits and rats[J];Chinese Pharmacological Bulletin;1992-04
3 Li Lifan Zhen Zhimin Biochemical department, Youjiang Medical College for Natinal Minorites, Baise, Guangxi, China 53300;Paederia yunnansis can protect the mice′s injured liver[J];JOURNAL OF YOUJIANG MEDICAL COLLEGE FOR NATIONALITIES;1996-02
4 LIU Tao shi, HUANG Yao zhou (Nanjing University of TCM, Nanjing 210029, China);Protective Effects of Ganshao Injection on Experimental Liver Injury in Mice[J];CHINESE TRADITIONAL PATENT MEDICINE;2000-05
5 Yao Wenbing, Chen Qionghua Division of Biochemistry;Biochemical Studies of Chinese Rhubarb ⅩⅩⅩⅡ Organism-Protecting Actions of Rheum Hotaoense Polysaccharide[J];Journal of China Pharmaceutical University;1991-01
6 Wu Chunmin and Chen Qionghua Division of Biochemistry;Cytoprotection Action of the Polysaccharide from Auricularia Polytricha Sacc[J];Journal of China Pharmaceutical University;1991-05
7 Chen Shuang, Ben Chang'er, Yang Meijuan, Wang Defu Beijing University of TCM (Beijing, 100029);Rat's Hepatocellular Damage Protected and Treated by Paeoniflorin: Morphological and Biochemical Research in Vitro[J];Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases;1997-04
8 Liu Guohua.et al.(Shandong institute for Drug Control, Jinan 250012);Toxicity and Pharmacologic Action of Yinzhihuang Oral Liquid on Experimental Liver Damage[J];TRADITIONAL CHINESE DRUG RESEARCH & CLINICAL PHARMACOLOGY;1995-02
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 SHI Yan,DING Xiang (1.The Second Hospital of Jiangsu Huai’an, Huai’an 223002, China; 2.The First Hospital of Jiangsu Lianyungang, Lianyungang 222002, China);Observation on effectiveness of MTX and TGP on rheumatic arthritis with childrenshiyan[J];Anhui Medical and Pharmaceutical Journal;2004-06
2 HU Cheng-mu,JIANG Hui,LIU Hong-feng,LI Rong,LI Jun (School of Pharmacy,Anhui Medical University,Hefei 230032);Effects of LJTF on immunological liver injury in mice[J];Anhui Medical and Pharmaceutical Journal;2008-04
3 CHEN Fang-jun1,2,WANG Jia-jia1,LI Jun1(1.Anhui Medical University,Hefei,230032;2.Anqing Medical College,Anqing,246003);Protective effect of polysaccharides from yu-ping-feng powder on immunological liver injury in mice[J];Anhui Medical and Pharmaceutical Journal;2008-04
4 SHAO Fu-rong,WEI Wei,LIU Hao,SUN Wu-yi,LI Xiang(Institute of Clinical Pharmacology of Anhui Medical University, Anhui Hefei 230032,China);Comparison of Protective Effect of Shaoqiduogan Extracted by Different Methods on Immunological Liver Injury in Mice[J];Journal of Anhui Traditional Chinese Medical College;2007-05
5 Wang Yuwei,Wang Yongjun Zhejiang Chinese Medical University Hangzhou(310053);Pharmacological Study and Clinical Application of Total Glucosides of Peony in Autoimmune Diseases[J];Journal of Zhejiang University of Traditional Chinese Medicine;2007-02
6 Shu Tao1,Fan Zhenhai2,Wu Qin3,Yang Guihe3,Yu Limei2,Dui Danhua1(1.Department of Hepatobiliary Surgery;2.Cell Engineering of Guizhou Province,Affiliated Hospital of Zunyi Medical College;3.Key Laboratory of Basic Pharmacology in Guizhou Province,Zunyi Medical College,Guizhou 563003,China);Liver protection of wei-le-san in acute obstructive suppurative cholangitis rats[J];Chongqing Medicine;2011-01
7 SHI Peng Department of Nephrology, PLA 451 Hospital, Xi'an 710054, China;Effects of total glucosides of paeony on active Heymann nephritis in rats[J];Journal of The Fourth Military Medical University;2005-18
8 ZHANG Mao-qing,MA Meng(Tai'an Hospital of Women and Children's Care, Shandong Tai'an 271000, China);Clinical application and improvement of the total glucosides of peony[J];Journal of Pediatric Pharmacy;2006-01
9 REN Feng-lian,QU Bai-lu and TAN Xiao-yan(College of Chemistry and Chemical Engineering,Central South University,Changsha 410083);Determination of total glucoside content of paeony in Paeonia lactifloria Pall.by Alkaline hydrolysis-UV spectrophotometry[J];Chinese Journal of Analysis Laboratory;2008-10
10 Guo Cuiping Zhumadian second Chinese Medicine Hospital ,Henan,Zhumadian 463000;Treatment of irritable bowel syndrome by Lipi Decoction for 34 cases[J];Guangming Journal of Chinese Medicine;2010-11
China Proceedings of conference Full-text Database 3 Hits
1 LIU Jun 1、2,ZHANG Jian-jun 2 (1. Guangzhou University of Chinese Medicine,Guangzhou 510405,China; 2.Guangdong Provincial Institute of Traditional Chinese Medicine,Guangzhou 510095,China);Optimization of the Processing Parameters for the Extraction of Total Glucoside of Paeony in Paeony Dispensing Granule using Box-Behnken experimental design[A];[C];2010
2 CHEN Gang,GUO Li-Xia,DENG Xiao-Hong,YIN Zhong-Yi,JING Jia-Jia (Research Center of Medical Chemistry and Chemical Biology,Chongqing Technology and Business University,Chongqing 400067,China);Effects and mechanism of total glucosides of paeony on nitric oxide and inducible nitric oxide synthase production in macrophages[A];[C];2010
3 Hu Chengmu Jiang Hui Liu Hongfeng Li Rong Li Jun (School of Pharmacy,Anhui Medical University,Hefei 230032);Protective effect of Lonicera japonica total flavone(LJTF)on immunological liver injury in mice[A];[C];2007
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 Jia Xiurong, Jiao Wencai, Wei Wenshu, Chen Mingzhu & Xu Shuyun ( Institute of Clinical Pharmacology, Anhui Medical University );ANTIINFLAMMATORY, ANTIPYRETIC AND ANALGESIC EFFECTS OF SUDOXICAM[J];Chinese Pharmacological Bulletin;1986-04
2 Wang Yongxiang et al;Pharmacological Effect of Total Glucosides of Paeony Root[J];Acta Universitis Medicinalis Nahui;1986-01
3 LIU Geng-tao, WEI Huai-ling and SONG Zhen-yu (Chen-yu Sung) (Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing);FURTHER STUDIES ON THE PROTECTIVE ACTION OF BIPHENYL DIMETHYL-DICARBOXYLATE (BDD) AGAINST EXPERIMENTAL LIVER INJURY IN MICE[J];Acta Pharmaceutica Sinica;1982-02
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