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《CHINESE PHARMACOLOGICAL BULLETIN》 2000-01
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Changes of phospholipase D activity of exudate leukocytes in rat carrageenan-induced pleurisy

LI Ping, LU YunBi, ZHOU HanLiang, CHEN JiQiang (Dept of Pharmacology, Medical School, Zhejiang University, Hangzhou 310031)  
AIM To observe the relationship between the changes of phospholipase D(PLD) activity in inflammatory leukocytes and inflammation in vivo METHOD Inflammation was carried out by the carrageenaninduced pleurisy in the rat, and the exudate volume, total account of influxed cells and total activity of myeloperoxidase in exudate which was the index of degranulation of neutrophils were measured as the severity of inflammation PLD activity was assessed by the enzymecoupled spectrophotometric assay RESULT PLD activity of influxed leukocytes increased 40~60 times than that of peripheral blood leukocytes taken from untreated animals which contain low levels of PLD activity 〔(014±003) μmol·g -1 ·min -1 〕, and the influxed cellassociated PLD activity peaked at 3 h after injection of the carrageenan However,the severity of inflammation peaked at 12 h after carrageenan injection 500 μg and 1000 μg carrageenan caused dosedependent exudation in the pleural cavity but no significant difference of PLD activity was observed at 12 h after injection of carrageenan Indomethacin(2 mg·kg -1 , ip) and dexamethasone(01 mg·kg -1 , ip) both significantly attenuated the pleural exudation and cellular influx at 6 h after injection of carrageenan but had no significant effects on influxed cellassociated PLD activity CONCLUTION These findings indicate that the PLD activity of inflammatory cells in rat carrageenaninduced pleurisy increased, and suggest that this increase of PLD activity is not a secondary but a primary effect in the present model of acute inflammation, and antiinflammatory mechanisms of low dose of indomethacin and dexamethasone are not linked to PLD
【Fund】: 国家自然科学基金资助课题!No39670836
【CateGory Index】: R96
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【References】
Chinese Journal Full-text Database 3 Hits
1 Bai Jing, Sun Mingyu , Wang Shouyong, et al. (Disciplinary Division of TCM Formulas, Beijing University of Traditional Chinese Medicine,Beijing 100029);Effects of different ingredient-combinations of Xiaochaihu Decoction on the rat model of pleuritis induced by carrageenan[J];Journal of Beijing University of Traditional Chinese Medicine;2005-01
2 LU Yun-Bi, JIANG Bo, ZHOU Han-Liang (Department of Pharmacology, School of Medical Science, Zhejiang University, Hangzhou 310031, China);Effects of salbutamol and sodium cromoglicate on phospholipase D activity during the degranulation of rat peritoneal mast cell[J];Chinese Journal of Pharmacology and Toxicology;2001-05
3 SUN Ming-yu, XIE Ming, ZHANG Na, et al Beijing University of Chinese Medicine, Beijing (100029);Effect of Xiaochaihu Decoction and Different Herbal Formulations of Its Components on Cytokines of Carrageenan Induced Pleuritis in Rats[J];Chinese Journal of Integrated Traditional and Western Medicine;2004-07
【Citations】
Chinese Journal Full-text Database 3 Hits
1 Chen Xiang-yin Yan Yi-zhao Zhang Bao-ling and Xi Pin-xiang(Institute of Basic Medical Sciences, Beijing);Dynamic Changes of Leukocytes and some Inflammatory Me-diators during Carrageenan-induced Pleurisy in Rats[J];;1988-03
2 Huang Yong; Wu Xinghong; Qureshi Imran Ahmad; Chen Huili(Department of Biochemistry, Public Health Ministry Key Lab of Glycoconjugate Research,School of Basic Medical Sciences, Shanghai Medical University, Shanghai 200032);DETERMINATION OF PHOSPHATIDYL CHOLINE SPECIFIC PHOSPHOLIPASE D USING ENZYME COUPLING COLORIMETRIC METHOD AND ITS APPLICATION[J];JOURNAL OF SHANGHAI MEDICA(UNIVERSITY);1997-05
3 LI Ping, ZHOU Han Liang, CHEN Ji Qiang (Department of Pharmacology, Zhejiang Medical University, Hangzhou 310031);Phospholipase D and Inflammation[J];PROGRESS IN PHYSIOLOGICAL SCIENCES;1999-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 TANG Xu dong, JIANG Jian qing, LIU Bao yu,ZHOU Kai,DING Sheng,YU Yong kang (Department of Thoracic and Cardiovascular Surgery,the General Hospital of Chengdu Military Region,PLA,Sichuan Chengdu 610083,China);Molecular Mechanism of Protective Effect of Total Saponins of Panax Notoginseny against Myocardial Ischemia Reperfusion Injury[J];Journal of Anhui Traditional Chinese Medical College;2003-01
2 GUO Hai feng,WANG Guang yi, DU Xiao hong(Dept.of General Surgery,The First Hospital, Jilin University,Changchun 130021,China);The Protective Effect of Melatonin on Acute Lung Injury Associated with Severe Acute Pancreatitis[J];Journal of Norman Bethune University of Medical Science;2003-02
3 TANG Xu dong, JIANG Jian qing, LIN Chang wen, et al Chengdu Army General Hospital (Chengdu,610083,China);Experimental Study on Effects of Total Saponins of Panax Notoginseny on Activation of NF-kB and Infiltration of PMN in Myocardial Ischemic-reperfusion Injury[J];Journal of Chengdu Unversity of Tarditional Chinese Medicine;2002-03
4 Liu ping;Xiao Nan;Diao; Youfang;Tian Kunlun;LiuRen(Research Institute of Surgery,Daping Hospital,The Third Military Medical University,Chongqing 400042);Protective Effect of N-acetylcysteine on Hepatic Damage Induced by Intestinal Ischemic-reperfusion in Rats[J];CHONGQING MEDICAL JOURNAL;1998-06
5 Tian Kunlun,Xiao Nan, Diao Youfang, Liu Ping, Lin Ren (The Third Military Medical College,Chongqing (400042));The Protective Effect of N-acetylcysteine oil Intestine and Lung Damage Induced by Superior Mesenteric Artery Occlusion[J];CHONGQING MEDICAL JOURNAL;1999-02
6 LI Xing wang,ZENG Bang xiong,XU Tao,et al (1.Department of Anesthesiology,Union Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;2.Department of Thoracic Surgery,Harbin Railway Central Hospital,Harbin 150001,China);Protective effect of genistein on endotoxin-induced acute lung injury in rats[J];Chongqing Medical Journal;2003-12
7 LI Xing-wang,DONG Sheng,XIE Yu-bo,JIN Shen-wei,LIAN Qin-quan. Department of Anesthesiology,Second Affiliated Hospital,Wenzhou Medical College,Wenzhou 325027,China;Protective effect of genistein on endotoxin-induced acute lung injury in rats[J];Journal of Chinese Physician;2006-11
8 ZANG Chuan-bo~* WU Rong-qian SONG Xu-hua XU Ying-xin LI Rong (Department of General Surgery,General Hospital of PLA,Beijing 100853,China);Mechanism of liver and lung injury in septic mice[J];Academic Journal of Second Military Medical University;2007-06
9 Yang Zili; Wang Zhengguo; Zhu Peifang (Research Institute of Field Surgery, Daping Hospital, Third Military Medical University, Chongqing,400042 );The changes of NO and its synthase in the lungs during acute lung injury in rats[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;1998-04
10 Diao Youfang; Xiao Nan; Tian Kunglun; Liu Ping; Liu Ren (Research Institute of Field Surgery, Daping Hospital Third Military Medical University, Chongqing,400042);Effects of N-acetylcysteine on anti-lipid peroxidation injury during intestinal ischemio-reperfusion shock in rats[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;1999-06
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 YAN Shun qin,WU Shu qin,FENG Liang yuan,XU Zhao lan,ZHANG Lu jun (The First Dept.of Clinic Medicine,Anhui College of TCM,Anhui Hefei 230038,China);MECHANISM FOR ANALGESIC ACTIONS OF SHAOYAO GANCAO DECOCTION[J];Journal of Anhui Traditional Chinese Medical College;2001-06
2 Yang Huiling Guo Yubiao Ma Zhikai, et alDepartmetn of Pathophysiology, Sun Yat sen University of Medical Sciences, Guangzhou, 510089;Effect of xiao chai hu tang on tumor weight andplasma endothelin content in mice bearing sarcoma180[J];CHINESE JOURNAL OF CANCER;1998-06
3 Tu Weifeng, Xi Wenbing, Wei Jianqi, et al. The Center of Anesthesiology, General Hospital of Guangzhou Command of PLA, Guangzhou 510010;Microassay and clinical application of plasma elastase[J];Guangdong Medical Journal;2002-04
4 LIU Jian-ping~(1.2),LIU Zhong-hua~1,LI Xinghui~1,YOU Bao-chang~2(1.Key Laboratory of Tea Science,China Ministry of Education,Hunan Agriculture University,Changsha 410128,PRC;2.Yantai Campus,China Agricultural University,Yantai 264000,PRC);Progress on Anti-allergic Reaction Bioactive Constituents from Natural Products[J];Hunan Agricultural Sciences;2006-05
5 Xie Ming (谢 鸣) (Beijing University of Traditional Chinese Medicine,Beijing 100029);Reflection on the Research and Development of Chinese Medicine[J];JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;2000-02
6 Hong Ying, et al.(Pharmacology Section, Beijing University of TCM, 100029);Experimental Research on the Protective Effect of Minor Bupleurum Decoction and Xiangsha Six Gentlemen Decoction on Gastric Mucosa[J];JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1994-05
7 WU Fu xuan 1 DING Wen hui 1△ LI Da yuan 1 ZHANG Jun hua 1△△ MA Hui fang 2 ZHU Guo ying 1 WANG Li hui 1 ( 1Cardiovascular Department,First Hospital,Beijing Medical University,Beijing 100034; 2Department of Internal Medic;Experimental study on the effects of inflammatory mediators in myocardial ischemia reperfusion injury[J];JOURNAL OF CLINICAL CARDIOLOGY;2000-02
8 Yuerong Ma, et al(Department of pathology, Luzhou Medical college);EFFECTS OF XIAO CHAI HU TANG ON EXPERIMENTAL HEPATIC FIBROSIS IN RATS[J];JOURNAL OF LUZHOU MEDICAL COLLEGE;1997-02
9 Zheng Yongtang & Ben Kunlong (Kunming Institute of Zooloy,Academia Sinica, Kunming 650107);Use of MTT Assay for the Determination of Cell Viability and Proliferation[J];Immunological Journal;1992-04
10 YANG Ling,LIN Jian-hai. (Shanghai Second University of Med.Science Affiliated Xinhua Hosp.Shanghai 200092,China);Study on interlukin and thromboxane in patients with asthma on acute episode[J];NINGXIA MEDICAL JOURNAL;1999-12
【Secondary References】
Chinese Journal Full-text Database 9 Hits
1 LUO Gang-jian,GAN Xiao-liang,SHEN Ning,HEI Zi-qing,LI Shang-rong,CHEN Li-xin Department of Anesthesiology,Third Affiliated Hospital,SUN Yat-sen University,Guangzhou 510630,China;Cromolyn sodium ameliorates rat left cardiac function during intestinal ischemia-reperfusion[J];Journal of Southern Medical University;2007-05
2 SHEN Ning,GAN Xiao-liang,PANG Hu-yu,HE Zi-qing Department of Anesthesiology,Third Affiliated Hospital of Sun Yat-sen Uviversity,Guangzhou 510630,China;Role of sodium cromoglycate in brain protection and its effects on tumor necrosis factor-α and interleukin-1β after global cerebral ischemia-reperfusion injury in gerbils[J];Journal of Southern Medical University;2009-03
3 HEI Zi-qing~(1,*),GAN Xiao-liang~1,LI Shang-rong~1,et al Department of Anesthesiology,3 rd Affiliated Hospital,SUN Yat-sen University,Guangzhou 510630,China;Cromolyn sodium protect lung injury caused by intestinal ischemia reperfusion in rats[J];International Journal of Anesthesiology and Resuscitation;2006-06
4 ZHANG Jia1,2,LI Peng2,LI Yi-kui2,LI Lian-da2(1.School of Basic Medical Science,Beijing University of Chinese Medicine,Beijing 100029,China;2.Experimental Research Center of Xiyuan HosPital,China Academy of Traditional Chinese Medicines,Beijing 100091,China);Effect on Tween 80 on the degranulation of RBL-2H3 cells[J];Current Immunology;2009-03
5 GAN Xiao-liang,HEI Zi-qing,LUO Gang-jian,LI Shang-rong,CHEN Li-xin,CAI Jun(Department of Anesthesiology,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China.);Effects of mast cell membrane stabilizer on histamine concentration,MDA content and SOD activity in small intestine after ischemia-reper-fusion injury in rats[J];Chinese Journal of Pathophysiology;2008-01
6 ZHANG Wei,XIE Can-mao.Department of Respiratory Medicine,The Central Hospital of Tai'an.Tai'an,Shandong 271000,China;Expression of aquaporin-1 in rat model of carrageenan-induced pleural effusion[J];Chinese Journal of Respiratory and Critical Care Medicine;2008-03
7 JIA Yinjie,YI Hong,PEN Bo,LI Jianyong,YANG Hua(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China);Inhibiting effect of Shuang-huang-lian microemulsion on cytokines of carrageenan induced pleuritis in rats[J];China Journal of Chinese Materia Medica;2009-06
8 ZHANG Rui,CHEN A-qin,YU Song-dong,YANG Zhi-gang,(College of Animal Science,Zhejiang University,Hangzhou,Zhejiang 310029,China);Recent Advance in Studies on Anti-inflammatory and Immunopharmacological Activities of Radix bupleuri[J];Chinese Journal of Veterinary Drug;2006-03
9 ZHANG Yan-ping, DENG Xu-ming, CHEN Zhi-bao (Quartermaster University of PLA, Changchun Jilin 130062, China);Preliminary study of anti-inflammation mechanism about Cucurbita pepo cv Dayangua[J];Journal of Traditional Chinese Veterinary Medicine;2004-06
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Ai, Zhao-wei Zha, Xi-liang Tang, Hua Chen, Hui-li (Department of Biochemistry, Shanghai Medical University, Shanghai);The Reverse Effect of Retinoic Acid on Human Hepatocarcinoma Cell Line——Biological Studies[J];;1990-02
2 Li He(Institute of Basic Medical Sciences, Beijing);The Effects of Electro-acupuncture on Exudate Volume and TXB2,6-Keto-PGF_(1α) Contents in Pleural Cavity after Carrageenin-Induced Pleurisy in Rats[J];Acta Academiae Medicinae Sinicae;1987-04
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