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《CHINESE PHARMACOLOGICAL BULLETIN》 2000-01
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Effects of biatractylolide on isolated guinea pig myocardium

PU HanLin,WANG ZhengLian,HUANG QiaoJuan,XU ShiBo,LIN YongCheng1,WU XiongYu1 (Dept of Pharmacy, 1School of Chemistry and Chemical Engineering,Zhongshan University, Guangzhou 510275)  
AIM To study the effects of biatractylolide on isolated guinea pig atrium. METHODS The isolated rat atria were adopted. Before and after giving biatractylolide,verapamil, the heart rate, contractile force of atrium, postrest contraction and staircase were measured. RESULTS Biatractylolide could prominetly inhibit contractile force and decrease heart rate of isolated right atrium of guinea pig. These actions could be blocked by atropine completely. It could inhibit positive staircase phenomenon of isolated left atrium of guinea atrium. It had no effect to the PREP of the isolated left atrium. CONCLUSION Biatractylolide possessed negative inotropic and chronotropic actions on isolated guinea pig.
【CateGory Index】: R285
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