The effects of TGP on CJ-S_(131)-induced systemic lupus erythematosus-like model in mice
ZHOU Ling Ling 1, WEI Wei, SHEN Yu Xian, XU Shu Yun (Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032) 1Dept of Pharmacology,Nanjing University of Traditional Chinese Medicine,Nanjing 210029
AIM To investigate the effects of TGP on immunologic changes associated with CJ S 131 induced SLE like model in mice. METHODS SLE like syndrome was induced by injection of CJ S 131 and CFA.Various doses of TGP were given by gavage once daily for 28 days. RESULTS The levels of IgG anti single stranded DNA(ssDNA) and histone autoantibodies were increased in sera four weeks after injection.The proliferation response of splencytes to ConA and LPS and the production of IL 1 were also increased. TGP(50,100,200 mg·kg -1 ·d -1 ,ig) inhibited the aboved changes of SLE like mouse model partly or completely. CONCLUSION The SLE mouse model was similar to idiopathic SLE in humans. TGP has modulating effects on alternations of immunity of SLE like mouse model.