Pathological significance and mechanism of advanced glycation end-products
SUN Mian En,DU Guan Hua ( Chinese Academy of Medical Science & Chinese Union Medical College,Beijing 100050)
Advanced Glycation End products (AGEs) are the products of non enzymatic glycationprotein. It has been demonstrated that AGEs are closely correlated to a variety of diseases such as diabetes,vascular complications,aging and renal diseases. AGEs play important roles in the development of these diseases. They can effect the function of cells and tissues directly, and also mediate pathological reactions through binding with special receptors. The present paper reviews the procedures of AGEs production,action mechanism and pathology of AGEs.