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《Chinese Pharmacological Bulletin》 2003-03
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Therapeutic effect of glucosides of chaenomeles speciosa on adjuvant arthritis in rats

DAI Min 1, WEI Wei, WANG Ni Ping, CHEN Qun (Institute of Clinical Pharmacology, Anhui Medical University,Hefei 230032)  
AIM To investigate the therapeutic effect and mechanism of glucosides of Chaenomeles speciosa (GCS) on adjuvant arthritis (AA) in rats. METHODS Complete Freund's adjuvant was used to induce AA in rats. Secondary paw swelling of AA rats was measured with volume meter. Pain response and polyarthritis index were scored. Meanwhile, ConA induced thymocyte proliferation and LPS induced splenocyte proliferation were assayed by 3 (4,5 dimethylthiazol 2 thiazolyl) 2,5 diphenyl 2H tetrazolium bromide (MTT) assay. IL 1 production was measured by thymocyte proliferation assay; TNF α and PGE 2 production were determined by radio immunoassay. RESULTS GCS (30, 60, 120 mg·kg -1 ) and Actarit (60 mg·kg -1 ) were given by intragastric administration for 8 days from the 17th day after immunization. Treatment with GCS (60, 120 mg·kg -1 ) and Actarit (60 mg·kg -1 ) for 5 days significantly diminished the secondary hind paw swelling, as well as relieved the pain response and the polyarthritic symptoms of the whole body as compared with AA model group. GCS (120 mg·kg -1 ) and Actarit (60 mg·kg -1 ) restored the diminished thymocytes proliferation ConA induced in AA rats. GCS reduced the enhanced productions of IL 1,TNF α and PGE 2 from peritoneal macrophages in AA rats. CONCLUSION GCS has therapeutic effect on AA in rats, which may be related to regulation function of thymocyte T cells and inhibiting the productions of proimflammatory cytokines secreted by peritoneal macrophages.
【Fund】: 安徽省自然科学基金资助课题No 0 0 0 44 411;; 安徽省“十五”科技重大专项资金资助课题No 0 180 3 0 2 6;; 合肥市重点科技项目资助课题No 2 0 0 1 48 14
【CateGory Index】: R285
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