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《Chinese Pharmacological Bulletin》 2003-07
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The effects of angelica sinensis on pulmonary fibrosis in rats

CHAI Wen Shu, LI Yong Chun, WANG Hong Xin 1, GUO Min 1,LI Yan Qin 1 (Dept of Respiratory Medicine,The First Affiliated Hospital, 1Jinzhou Medical College,Jinzhou 121001)  
AIM To observe the effect of Angelica Sinensis on bleomycin induced pulmonary fibrosis in rats. METHODS Seventy two SD rats in good conditions were divided into four groups at random:control group,model group,Angelica Sinensis group one and two. On the experiment day(d 0),the rats were intratracheally instilled with bleomycin(5 mg·kg -1 body weight),and then treated with angelica sinensis 100 mg·kg -1 and 200 mg·kg -1 until they were killed. On d 7,14,28 after instillation ,six rats of each group were sacrified and the lungs were harvested for histopathological examination and determinations of GSH and HA. RESULTS Volume proportion of alveolar air and capillary increased and volume proportion of interstitial decreased in angelica sinensis groups compared with BLM group( P 0 01). The content of GSH in lung tissue increased significantly( P 0 01), while the content of HA decreased in angelica sinensis groups compared with BLM group( P 0 01).CONCLUSION Angelica sinensis may alleviate the process of rat pulmonary fibrosis induced by bleomycin and has therapy effect on pulmonary fibrosis in rats in early period.
【Fund】: 辽宁省教育厅资助项目No 980 52 110 52
【CateGory Index】: R285.5
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