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《Chinese Pharmacological Bulletin》 2004-02
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Protective effect of TGP on complete cerebral ischemia reperfusion injury in rats

LIU Wei, WU Hua-Pu, ZHU Xiao-Guang,MING Liang-(Dept of Pharmacology,Huaibei Vocational and Technical college,Huaibei 235000)--  
AIM To study the protective effect of total glucosides of paeony(TGP)on complete cerebral ischemia reporfusion injury and its mechanism of action.METHODS A complete cerebral ischemia[FQ(10。46,X-WZ]- reperfusion model of rats was induced by clipping three arteries. The changes in eye colour, SOD activity, MDA contents and histopathological characteristics were observed. RESULTS TGP (TGP 10、20、40 mg·kg -1 ) markedly reduced the change of eye colour; TGP(20 mg·kg -1 ) obviously elevated SOD activity decreased and inhibited the MDA of increased contents of cerebral cortex, hippocampus and corpus striatum of cerebral ischemia reperfusion in rats; TGP(20 mg·kg -1 )possessed protective effects on the histopathological changes of ischemia cerebral tissues in rats. CONCLUSION TGP possessed obvious protective effects on the cerebral ischemia reperfusion injury, suggesting that the protective action of TGP is relative to anti-oxidative action.-
【Fund】: 安徽省教育厅资助项目 No 97JL165
【CateGory Index】: R285
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