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《Chinese Pharmacological Bulletin》 2004-03
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Effects of puerarin on pulmonary vascular structure of chronic hypoxia in rats

FAN Xiao-Fang, LI Ji-Wu ,GONG Yong-Sheng, HU Liang-Gang, HUANG Hong, LUO Jia n-Feng(Institute of Cor Pulmonale,Wenzhou Medical College,Wenzhou325027)  
AIMTo investigate the effects of puerarin on pulmonary vascular structure in pulmonary hypertension rats induced by chronic hypoxia. METHODSThirty male spragu-dawley rats were randomly divided int o three groups:control group(NC), hypoxia group(HH), hypoxia+puerarin group(HP). Collagen Ⅰ, Ⅲ and collagen I mRNA were observed in pulmonary arterioles by th e technique of immunohistochemistry and in situ hybridization. RESULTS①mPAP was much higher in rats of HH group than that of NC group(P0 01), and lower in HP group than that in HH group(P0 01). Differences of mC AP were not found among three groups(P0 05). ②The contents of lung homoge nates SOD and MDA of HP group were obviously higher than those of HH group(P 0 01). ③The levels of plasma ET-1 and NO were much higher in rats of HH group than those of NC group(P0 01),[FQ(10。46,X-WZ]and lower in HP group than those in HH group (P0 01). ④Percentage of muscularized artery, relative media t hickness(RMT) and relative media area(RMA) were much higher in HH group than tho se of NC group, HP group were much slighter than those of HH group(P0 01). ⑤Expression of collagen I and collagen I mRNA in pulmonary arterioles were sig nificantly higher in rats of HH groups than those of NC group (P0 01),and they were lower in rats of HP group than those of HH group (P0 01). Expre ssion of collagen Ⅲ was no difference among three groups(P0 05). CONCLUSIONPuerarin can improve pulmonary vessel remodeling.
【Fund】: 浙江省教委基金资助项目 No 2 0 0 2 0 4 6 8
【CateGory Index】: R285
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