Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Pharmacological Bulletin》 2004-05
Add to Favorite Get Latest Update

Protective effects of extract of astragalus on injuries of global cerebral ischemia and reperfusion in rats and anoxia in mice

HE Ting, MING Liang, WANG Shao-Bin, WU Qiang, YIN Yan-Yan, LI Wei-Ping (Dept of Pharmacology, Anhui Medical University, Hefei 230032)  
AIM Protective effects of extract of astragalus on injuries of global cerebral ischemia/reperfusion in rats and anoxia in mice. METHODS Acute anoxia in mice were produced by hypoxia under normal pressure and decapitation. In these two models the survival time and persistent time of gasping were observed. The global ischemia and reperfusion in rats was made by four-vessel occlusion (4-VO). After 20 min ischemia and 24 h reperfusion, the brain index and water content in brain was detected. MDA content and SOD activity of brain homogenate were tested. Endothelin concentration was determined both in plasma and hippocampus. The pathological changes of cortex tissue were observed by light microscope. RESULTS EA(50,100 mg·kg -1) significantly prolonged the survival time and persistent time of gasping in mice subjected to acute anoxia. EA(20,40,80 mg·kg -1) markedly reduced brain edema induced by global ischemia and reperfusion. EA(40,80 mg·kg -1) decreased MDA content and increased SOD activity in brain homogenate, and also inhibited ET concentration both in plasma and hippocampus. The pathological changes of cortex tissue were less serious in rats treated with EA. CONCLUSION EA has protective effects on cerebral ischemia and anoxia injuries that may relate to anti-oxidation and inhibition of ET production.
【Fund】: 安徽省“十五”科技重点专项基金资助 No 0 180 3 0 16;; 安徽省自然科学基金资助 No 0 0 14 44 14
【CateGory Index】: R285
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Yue,HUANG Nenghui,ZHANG Xiaoyi,LUO Jun(Department of Pharmacology,Guiyang Medical College,Guiyang 550004,China);An Experimental Study on the Anti-fatigue and Anti-hypoxia Effects of Ganoderma lucidum Triterpenoids to Mice[J];Journal of Guiyang Medical College;2007-02
2 BAI Xue,XIAO Haitao,YANG Jie,ZHU Jie,HAO Xiaoyan(School of Pharmacology,Guiyang Medical College,Guiyang 550004,Guizhou,China);An Experimental Study on the Anti-stress Effects of Alkaloids in Rhizoma Corydalis to Mice[J];Journal of Guiyang Medical College;2008-02
3 Liang Yan,et al(Guiyang Medical University,Guiyang 550004);Study on the Anti-fatigue and Anti-hypoxia Effects of Tianshenyizhi capsule to Mice[J];Journal of Mathematical Medicine;2009-04
4 MIN Xiao-fen, LI Wei-ping, WANG Shao-bin,HE Ting, YIN Yan-yan, MING Liang (Dept of Pharmacology, Anhui Medical University,Hefei 230032,China);Anti-oxidative and mitochondria-protective effects of extract of astragalus on focal cerebral ischemia-reperfusion injury in rats[J];Chinese Pharmacological Bulletin;2005-02
5 LI Wei-zu, MING Liang,HE Ting,WANG Shao-bin,LI Wei-ping(Dept of Pharmacology, Anhui Medical University, Hefei 230032,China);Effects of extract of astragalus on hippocampal delayed neuronal death in rats[J];Chinese Pharmacological Bulletin;2005-05
6 YIN Yan-yan, LI Wei-ping, WANG Shao-bin,HE Ting, MING Liang (Dept of Pharmacology,Anhui Medical University, Hefei 230032, China);Effect of extract of astragalus on inflammatory factor and apoptosis after focal cerebral ischemia/reperfusion injury in rats[J];Chinese Pharmacological Bulletin;2005-12
7 Cao Xi,Li Weiping, Wang Shaobin et al (Dept of Pharmacology, Anhui Medical University, Hefei 230032);Protective effect of extract of astragalus against focal cerebral ischemia-reperfusion injury[J];Acta Universitis Medicinalis Nahui;2005-05
8 Li Jing, Ming Liang, Huang Rongrong(Dept of Pharmacology, Anhui Medical University, Hefei 230032);Effects of extract of astragalus on IL-1β,TNF-α and IL-6 expressions after global cerebral ischemia and reperfusion[J];Acta Universitis Medicinalis Nahui;2005-06
9 Wu Guocui,Li Jing,Li Weiping,et al(Dept of Pharmacology,Anhui Medical University, Hefei 230032 );Effects of astragalus extract on NFκBp65,ICAM-1 and TNF-α expression after global cerebral ischemia and reperfusion in rats[J];Acta Universitatis Medicinalis Anhui;2008-04
10 LI Jing,MING Liang,HUANG Rong-rong, CAO Xi, WU Qiang~1, LI Wei-pingDepartment of Pharmacology, ~1 Department of Pathematology, Anhui Medical University, Hefei 230032,Anhui, China;Effects of extract of astragalus on inflammatory reaction during global cerebral ischemia and reperfusion in rats[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2005-09
【Citations】
Chinese Journal Full-text Database 5 Hits
1 XU Du Juan, WU Qiang, YANG Yan, CHEN Ming Zhu (Institute of Clinical Pharmacology,Anhui Medical University,Hefei 230032);Antitumor activity of AST and its mechanism of action[J];Chinese Pharmacological Bulletin;2003-07
2 LI Li Hua, KU Bao Shan, RAO Yu (Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100083, China);Effects of melatonin on oxidization injury and on expression of P53 protein during ischemia-reperfusion in brain tissue of rats[J];Chinese Journal of Pharmacology and Toxicology;2001-06
3 ZHANG Yan MING Liang LI Wei-Ping LI Jing-Pei CHEN Min-Zhu(Department of Pharmacology, Anhui Medical University, Hefei, 230032);Effect of extracts of astralus on learning,memory and immune function in mice[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2000-02
4 CHEN Cong ying, LU Yang, CHEN Ze nai (Department of Chemistry, Shanghai Second University of Medical Sciences, Shanghai 200025, China);Survey of studies on Astragalus membranaceus var. mongolicus[J];Chinese Traditional and Herbal Drugs;2001-06
5 SONG Zong-hua1, DAI Shu-jia1, LI Hui-qin1, BI Kai-shun1, FENG Dong2 (1.Shenyang Pharmaceutical University, Shenyang 110015, Liaoning, China; 2.Beijing Zhongshun Pharmaceutical Factory,Beijing 101300, China);Study on the Compatibility of Composite Herbal Medicinesof the LingGuiZhuGan Decoction[J];China Journal of Chinese Materia Medica;2002-10
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LI Jing,LIU Xin,GAO Luan Tutor:Professor WANG Jian (Anhui College of Traditional Chinese Medicine, Anhui Hefei 230038,China);Effect of Therapy of Qi-supplementing,Blood-activating and Qi-supplementing & Blood-activating on Hemorrheology in Rats with Qi Deficiency & Blood Stasis Syndrome Following Cerebral Ischemia-reperfusion[J];Journal of Anhui Traditional Chinese Medical College;2004-03
2 ZHOU Hong-yan1, MAO Hai-feng2, WANG Yi-rong2, LIU Ren-yi2 (1.Department of Physical Education, Hunan University of Arts and Science, Changde Hunan 415000; 2.Physical Education Institute, Hunan Normal University, Changsha Hunan 410081);Progress of Study in Cerebral Ischemic Damage[J];;2005-02
3 LUO Xue-ya, GAO Wei, LUN Yong-zhi, JIN Li-xin, ZHAO Lian-hua, CAO Li-li(Medical College of Dalian University, Dalian 116622, China);Studies on acute toxicity of Astragalus composition F_3 new preparation[J];Journal of Dalian University;2002-06
4 XU Ping-ping,TAN Yin-chun,YU Hong-shan,JIN Feng-xie School of Biological & Food Engineering,Dalian Polytechnic University,Dalian 116034,China;Increasing astragaloside Ⅳ extraction by enzyme reaction[J];Journal of Dalian Polytechnic University;2009-01
5 CHEN Feng,WANG Jiang-Kun,WANG De-Gui,HOU Yi-Ping,SONG Yan-FengInstitute of Neurobiology,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China;Protective effect of atorvastatin on acute cerebral ischemia injury in rats[J];Journal of the Fourth Military Medical University;2008-07
6 CHEN Zong-yun, WANG Jing-yu, LI Yong-hong (Department of forensic medicine, Wannan Medical College, Wuhu 241000, China);The Expression of NGF after Rat Diffuse Axonal Injury[J];Journal of Forensic Medicine;2008-03
7 Chuanhong, Lai Huangwen, Tang Gengyun, et al. General Hospital of Guangzhou Command of PLA , Guangzhou 510010;Expression of endogenous NGF in brain areas and cerebella of aged rats on reperfusion following cerebral ischemia Yang[J];Guangdong Medical Journal;2002-09
8 ZENG Xiao-chun1,ZHONG Li-ye2 (1.XiangNan Institute of Oncology, Chenzhou, Hunan 423000;2.Guangdong Provincial People's Hospital, Guangdong Guangzhou 510080);Non-Hodgkin's lymphoma in patients with BFGF expression and the influence of astragalus injection[J];Journal of Gannan Medical University;2008-03
9 JING Li-Xin ZHAO Lian-Hua QIU Hong-Jiu CAO Li-Li LUO Xue-Ya (Medical College,Dalian University, Dalian,Liaoning 116622,P.R.China);Technological Monitoring Measurement in New Preparation-Component F3 of Astragalus Membranaceus[J];Chinese Journal of Spectroscopy Laboratory;2003-01
10 Zhang Dongqing,Wang Deqing.Department of Clinical Laboratory,First Hospital Affiliated to the Chinese PLA General Hospital,Beijing 100048,China;Effect of total flavonoids of Astragalus on human hepatoma cancer cells by using proteomic analysis[J];Infection,Inflammation,Repair;2009-01
China Proceedings of conference Full-text Database 1 Hits
1 Yuan Rongfeng luo lingfang Gao xiooping Ji yong xia. Department of Neurology,Hunan Teacher,s Uni- versity,s First Affiliated hospital Changsha 410005,China;To study the Relationship Between Asyptomatic Cerebral Infarction And Vascular Cognitive Impairment[A];[C];2007
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Wang Yuanjing,Shen Guoming,Wang qinmao (Department of Combination of Chinese and Western Medicin, Anhui College of TCM,Hefei 230038,China);THE PROTECTIVE EFFECTS OF LIGUSTRAZINE ON ACUTE CEREBRAL ISCHEMIA REPERFUSION INJURY IN RATS[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;2000-01
2 QU You-zhi,ZHAO Yan-ling,ZHAO Wen-ying,GAO Guo-dong,XIA Tian (Deptartment of Neurosurgery,Tangdu Hospital,The Fourth Military Medical University,Shaanxi Xi'an 710038,China);PROTECTIVE EFFECTS OF ERIGERON INJECTION ON CEREBRAL ISCHEMIC AND REPERFUSION INJURY[J];Journal of Anhui Traditional Chinese Medical College;2001-03
3 LI Ping,ZHANG Mei (Dept.of TCM,Anhui Provincial Hospital,Anhui Hefei 230001,China);EFFECTS OF ASTRAGALUS ON APOPTOSIS RELATED GENE EXPRESSION IN RATS AFTER CEREBRAL ISCHEMIA[J];Journal of Anhui Traditional Chinese Medical College;2001-04
4 LI Hong 1,LAN Feng ying 2,RUN Da yong ,CAO Rui min 1, WANG Zhen xue ,YANG Bao feng 1,YANG Shi jie 1 (1 Dept.of Pharmacology,School of Basic Medical Sciences,Jilin University, Changchun 130021 China; 2\ Changchun Medical Professional;Preliminary study on detoxification of jasmine root extract[J];Journal of Norman Bethune University of Medical Science;2001-03
5 Liu Juyan ( The First Military Medical University , Guangzhou );The Changes in Hypothalamus - pituitary - testicle Axis Chronic Mor Dependence - abstinence Rats and Patients and Clinical and Experimental Study of "Warming Yang, Replenishing Energy, Invigorating Blood Circulation and Eliminating Blood Stasis Co[J];China Journal of Traditional Chinese Medicine and Pharmacy;2001-01
6 YUAN Guo hong,GAO Wei juan,MENG Fan xing,et al (Department of Pathophysiology,Chengde Medical College,Hebei Chengde,067000,China);EFFECT OF YISHENJIANGZHUO DECOCTION ON INTRACEREBRAL ACHE ACTIVITY OF ISCHEMIA REPERFUSION RAT[J];Journal of Chengde Medical College;2001-02
7 JU Hong Wei, JIANG Xue Tao, ZHONG Yan Qiang, LI Guo Dong, GAO Shen(Department of Pharmaceutics,College of Pharmacy,Second Military Medical University, Shanghai 200433,China) [;Pharmaceutics and quality control of Compound Corydalis Granule and preliminary study of its effects on morphine-dependent rats[J];Academic Journal of Second Military Medical University;2001-03
8 WU Yi, ZHANG Xiang, WU Jing Wen, FEN Ya Ping,FEI Zhou,SONG Shao Jun, LIANG Jing Wen Institute Neurosurgier of Chinese PLA,Xijing Hospital,Fourth Military Medical University,Xian 710033,China;Experimental study of intracellular calcium change after craniocerebral fire-arm wounds in canines[J];Journal of The Fourth Military Medical University;2002-23
9 TIAN Ye, WAN Qi, LIU Yong Hong, LI LiDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xian 710033, China;Expression of nuclear transcription factor NF-κB in primary cultured neurons following ischemia reperfusion injury[J];Journal of The Fourth Military Medical University;2003-07
10 WANG Jun1, XIONG LiZe1, SONG LiQiang1, LUO JunXiang1, ZENG XiangLong1, LIU XiaoNing2, HU WenNeng1 1Department of Anesthesiology, Xijing Hospital, 2Laboratory of Central Electron Microscopy, Fourth Military Medical University, Xi'an 710033, Shaan;Effect of body moderate hypothermia on apoptosis in rat hippcampal CA1 after global cerebral ischemia and reperfusion[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1999-06
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Chaohu Vocational and Technical College,Chaohu 238000,Anhui LU Wei-zhuo;Mechanisms of astragalosides on cerebral ischemia in rats and PG relation[J];Journal of Anhui Health Vocational & Technical College;2007-04
2 GUO Fang,Lü Ping,LI Shu-Min,WANG Yong-Li Department of Pharmacology,Hebei Medical University,Shijiazhuang 050017,China;Change of Na~+,K~+-ATPase α isoforms in rat neurons damaged by global cerebral ischemia/reperfusion[J];Journal of the Fourth Military Medical University;2006-18
3 FAN Bao.The first hospital hospital affiliated tochangde vocstional Technical college,Changde 415000,China;Observation of ischemic cerebrovascular disease treated by Huangqi Zhusheye combined Low Molecular Heparin Clinical[J];International Medicine & Health Guidance News;2009-22
4 QU You-zhi, ZHAO Yan-ling, QIN Huai-zhou,et al.Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China;Effect of astragus injection on apoptosis of neuronal cell and expression of apoptosis-associated genes after cerebral ischemia and reperfusion[J];Nervous Diseases and Mental Health;2007-01
5 LAI Zhen1,LI Li-Shan1,and CHENG Shao-Bing2(1.Shenzhen People's Hospital,The Second Clinical Medical College,Jinan University,Shenzhen 518020,China;2.Department of Traditional Chinese Medicine,Jinan University,Guangzhou 510632,China);The Effect of Radix Astragali and Safflower Injection on Neuron Apoptosis and Caspase-8 After Local Cerebral Ischemia/Reperfusion in Rats[J];Chinese Journal of Arteriosclerosis;2008-11
6 WANG Hai-bin,DONG Wei-li,ZHANG Tie-min.SHI Jing,ZHANG Zhao (Department of Ophthalmology,Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China;Traditional Chinese Medicine with Boosting Qi and Nourishing Yin and Quickening the Blood and Transforming Stasis and Acupuncture in Treating Diabetic Retinopathy:A clinical report[J];Liaoning Journal of Traditional Chinese Medicine;2008-11
7 CHENG Qiong, ZHANG Junfang, DING Fei (Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001);Effects of nerve growth decoction on platelet aggregation and thrombosis formation[J];Nantong University Journal of Medical Sciences;2007-01
8 YI Jian,HUANG Xin,XIE Yong,YANG Yi,CHEN Xue-mei,LIU Baiyan(TCM University of Hunan,Changsha,Hunan 410208,China);Effect of Naodejian decoction on nerve function and infarct volume in rats after focal cerebral ischemia[J];Journal of Traditional Chinese Medicine University of Hunan;2010-01
9 HUANG Ping,WU Qinghe,ZHENG Detan,RONG Xianglu,LIN Huichao(Guangzhou University of TCM,Guangzhou 510405,China);Protective Effect of Compound Laminaria Granule on Rat Experimental Cerebral Ischemia[J];Jouranl of Guangzhou Uiversity of Traditional Chinese Medicine;2007-01
10 Yue Yang Hospital of Integrative Chinese & Western Medicine, Shanghai University of TCM Qigong Institute, Shanghai University of TCM ZHOU Yan-li GE Lin-bao DAI Ju-yun;Effect of Low Level Laser Irradiation on Acupoint Combined with Iontophoresis Therapy on Cerebral Energy Metabolism in Rats with Cerebral Ischemic-reperfusion Injury[J];Shanghai Journal of Traditional Chinese Medicine;2005-12
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 RAO Yu, KU Bao Shan (Department of Pharmacology, Peking University School of Basic Medicine, Beijing 100083, China);The mechanism of protective effects of melatonin on global ischemia/reperfusion induced brain injury in rats[J];Journal of Beijing Medical University;2001-02
2 Fang Ji-Nian (Shanghai Institute of Materia Medica,Academia Sinica,Shanghai) Wagner,H. (Institute of Pharmaceutical Biology,University of Munich,West Germany);Chemical Structure of a Glucan from Astragalus Mongholicus[J];Acta Chimica Sinica;1988-11
3 Shi Renbing , Liang Xiaoqiu , Liang Jichun ,et al. (Beijing University of Traditional Chinese Medicine, Beijing 100029) T6;Effects of Astragalus S4 On the Cellular Immune Function of Tumorigenic Mice in Chemotherapy and the Inhibitory Action[J];JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1999-02
4 Liu Hui,Li Jinrong,Hu Chuanzhen.College of stomatology of Hubei medical University,Wuhan(430079);Study of the Immunoenhancement and Anti-cancer Effect of Astragalus Membranaceus on Human Squamous Cell carcinoma Cell Line GNM[J];STOMATOLOGY;1999-02
5 Wang Deqing;Shen Wenmei;Tian Yaping;Sun Zhongyi),CongJianbo), WuKe)(Department of Biochemsitry,General Hospital of PLA, Beijing 100853,China; Institute of Radiation Medicine,Academy of Military Medical Sciences, Beijing 100850, China).;Scavenging Effects of Active Principles from Astragalus mongholicus Bunge on Oxygen Free Radicals Studied by ESR[J];PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS;1996-03
6 Wang Deqing;Shen Wenmei;Tian Yaping;Jiang Cien (Department of Biochemistry, General Hospital of PLA, Beijing 100853, China).;Protective Effect of Total Flavonoids Astragalus on DNA Strand Breaks in V79 Cells Induced by Hydrogen Peroxide and Gamma Rays.[J];PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS;1996-04
7 YANG Yan, CHEN Min Zhu (Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032);Effects of total astragalosides on hepatoma cells apoptosis and wtp53 expression[J];Chinese Pharmacological Bulletin;2001-04
8 WANG De-Qing;SHEN Wen-Mei;TIAN Ya-Ping et al(Dept.of Biochemistry, General hospital of PLA,Beijing 100853);The effects of the three components isolated from astragalus mongholicus bunge on scavenging free radical[J];CHINESE PHARMACOLOGICAL BULLETIN;1994-02
9 YANG Yan SONG Shao_Gang CHEN Min_Zhu(Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032);Effects of the total extract of astragalosides on the growth,AFP secretion and γ-GT activity of human hepatoma cells[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2001-01
10 ZQ HE and BQ Wang (National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050);ISOLATION AND IDENTIFICATION OF CHEMICAL CONSTITUENTS OF ASTRAGALUS ROOT[J];Acta Pharmaceutica Sinica;1990-09
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved