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《Chinese Pharmacological Bulletin》 2005-02
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Anti-oxidative and mitochondria-protective effects of extract of astragalus on focal cerebral ischemia-reperfusion injury in rats

MIN Xiao-fen, LI Wei-ping, WANG Shao-bin,HE Ting, YIN Yan-yan, MING Liang (Dept of Pharmacology, Anhui Medical University,Hefei 230032,China)  
Aim To study the anti-oxidative and mitochondria-protective effects of estract of astragalus (EA ) on focal cerebral ischemia-reperfusion injury and its mechanism in rats.Methods Middle cerebral artery occlusion(MACO) was used to induce focal cerebral ischemia-reperfusion model. After 24 h reperfusion,MDA, LD content and SOD activity of brain homogenate were tested. MDA content,SOD and ATPase activity in mitochondrion were also tested.Transmission electron microscopy was used to assess the ultrastructure dstruction. Results EA(20, 40, 80 mg·kg -1) significantly inhibited the increase of MDA, LD after cerebral ischemia-reperfusion. EA (40, 80 mg·kg -1) also inhibited the decrease of activit of SOD in rats. EA(20, 40, 80 mg·kg -1) inhibited the increase of MDA and inhibited the decrease of activities of SOD, Na+,K+-ATPase, Ca 2+,Mg 2+-ATPase in mitochondrion. The examination by transmission electron microscopy showed that EA (20, 40 mg·kg -1) protected the ultrastructure destruction. Conclusion EA had protective effects against focal cerebral ischemia reperfusion injuries via attenuating cerebral oxygen free radical(OFR)lipid peroxidation and protecting mitochondria.
【Fund】: 安徽省“十五”科技重点专项基金资助项目 (No01803016);; 安徽省自然科学基金资助项目 (No00144414)
【CateGory Index】: R285
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