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《Chinese Pharmacological Bulletin》 2005-05
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Effects of extract of astragalus on hippocampal delayed neuronal death in rats

LI Wei-zu, MING Liang,HE Ting,WANG Shao-bin,LI Wei-ping(Dept of Pharmacology, Anhui Medical University, Hefei 230032,China)  
Aim To study the effects of extract of astragalus on hippocampal delayed neuronal death of totalcerebral ischemia and 7 days reperfusion in rats.Methods Global ischemia was made by four-vessel occlusion. Electron microscope was used to observe the ultramicrostructure of dorsal hippocampal neurons.Light microscope was used to survey the structure of hippocampal neurons and to count the number of normal neurons in CA1 sector. Glial fibrillary acidic protein(GFAP) was detected by immune histochemistry.Results Compared with ischemia and reperfusion group(I/R),EA improved the ultrastructure of hippocampal neurons, suppressed the decrease of normal neurons in CA1 and degraded the expression of GFAP .The number of normal neurons in I/R group was 38±11.5,and in EA(20,40 mg·kg -1) groups,63±12.8(P0.05)and 77±16(P0.01)respectively. The number of GFAP positive cells in I/R group was 69±10.7, and in EA(20,40,80 mg·kg -1)groups,53±5.6(P0.05),39±7.1(P0.01)and 46±7.6(P0.05)respectively. Conclusion EA can restrain hippocampal delayed neuron death of global ischemia and 7 d reperfusion in rats. It may suppress hyperplasy of astrocytes (AS) in hippocampal CA1 sector.
【Fund】: 安徽省“十五”科技重点专项资助项目(No01803016);; 安徽省自然科学基金资助项目(No00144414)
【CateGory Index】: R285
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