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《Chinese Pharmacological Bulletin》 2005-06
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Study on the expression of α-SMA in rats with adriamycin-induced nephrothy and intervention of Valsartan on it

DING Yue-ling1,DING Ying-jun2,ZHAO Yu-yong2(1.College of Traditional Chinese Medicine, 2.College of Integrated Traditional andWestern Medicine,Hebei Medical University, Shijiazhuang 050091,China)  
Aim To observe the changes on the expression of α-SMA in rats with adriamycin-induced nephrothy and intervention of Valsartan. Methods The model group were made by unilateral nephrectomy with twice-adriamycin injections by caudal vein. Immunohistochemical method, flow cytometry and pathologic image analysis were used to observe the expression of α-SMA, FN and LN in rats. Results The expression of α-SMA was positive in the model group. Rates of positive cell and protein semi-quantitative analysis were more higher than the sham group(P0.01). FN, LN had over expression in model group, and it expressed slightly in Valsartan group(P0.01). Conclusion The model group had cell phenotype conversion in renal tubulointerstitium. Valsartan had an effect on inhibiting the expression of α-SMA, FN and LN.
【Fund】: 河北省卫生厅资助项目(No2003057)
【CateGory Index】: R96
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