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《Chinese Pharmacological Bulletin》 2005-07
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The effect of angitensin converting inhibitor and angiotensin Ⅱ receptor antagonist on experimental diabetic nephropathy-with transforming growth factor β_1

WANG Ying-xing1, LI Yuan-si2, CHENG Yan2, YE Shan-dong2 (1.Dept of Pharmacology, Anhui Medical College, Hefei,230001,China; 2.Dept of Endocrology, Anhui Provincial Hospital, Hefei 230001,China)  
Aim ① To observe the relationship between TGFβ_1 and diabetic nephropathy in experimental rats;② To explore the effects of ACEI-fosinopril and ATRA-losartan on renal TGFβ_1 in diabetic rats and their renoprotective mechanism. Method Four groups of rats were studied, A group:normal control rats;B group: strephtozotocin induced diabetic rats;C group:diabetic rats treated with fosinopril;D group: diabetic rats treated with losartan.Blood glucose, urinary excretion rates of albumin, TGFβ_1,as well as the expressions of TGFβ_1 protein and TGFβ_1 mRNA in renal cortex and the relative kidney were measured. Result ① The urinary excretion rates of albumin and TGFβ_1 in B,C ,D groups were significant higher than those in A group, fosinopril and losartan can decrease the urinary excretion rates of the two proteins but can’t make the rate normal. ② The expressions of TGFβ_1 protein in renal cortex in B group was much higher than that in other 3 groups, fosinopril and losartan can inhibit the expression of TGFβ_1. ③ The expressions of TGFβ_1 mRNA in renal cortex increased greatest in B group, fosinopril and losartan can low the expression. Conclusion The overexpression of TGFβ_1 protein and mRNA in renal cortex of diabetic rats may be one of the mechanisms of diabetic nephropathy. Fosinopril and losartan can suppress the expressions of TGFβ_1 protein and mRNA in renal cortex, decrease the urinary excretion rates of TGFβ_1. So alleviate the patholochanges in kidney.
【Fund】: 安徽省自然科学基金资助项目(No01041181)
【CateGory Index】: R587.1
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