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《Chinese Pharmacological Bulletin》 2005-12
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Effect of extract of astragalus on inflammatory factor and apoptosis after focal cerebral ischemia/reperfusion injury in rats

YIN Yan-yan, LI Wei-ping, WANG Shao-bin,HE Ting, MING Liang (Dept of Pharmacology,Anhui Medical University, Hefei 230032, China)  
Aim To study the mechanisms of protective effects of extract of astragalus against focal cerebral ischemia/reperfusion injury in rats. Methods Focal cerebral ischemia was induced by intraluminal thread occlusion of middle cerebral artery. Immunohistochemistry was used to determine expression of TNF-α,IL-1β was measured by radioimmunity, and the apoptosis was observed by TUNEL. Results EA(20、40、80 mg·kg -1,ig)could decrease the expression of TNF-α and the level of IL-1β and reduce cell apoptosis. Conclusion EA has inhibitory action on the increase in the expression of TNF-α,the level of IL-1β and the apoptosis of neurons induced by focal cerebral ischemia/reperfusion.
【Fund】: 安徽省“十五”科技重点专项课题资助项目(No01803016);; 安徽省自然科学基金资助项目(No00144414)
【CateGory Index】: R285.5
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