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《Chinese Pharmacological Bulletin》 2005-12
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Chemopreventive effect of curcuma and curcumin on liver injury induced by microcystins in mice

CHEN Hua, XUE Chang-gao, CHEN Tie-hui, WANG Jia-li, SUN Chang-sheng (Toxicological Laboratory of Chinese Medicine, School of Public Health, Fujian Medical University, Fuzhou 350004,China)  
Aim To study the chemopreventive effect of curcuma and curcumin on liver injury induced by microcystins(MC)in mice. Methods 52 male Swiss mice were randomly divided into 4 groups. They were group curcuma(ig of 20 g·kg -1 curcuma), group curcumin ( ig of 300 mg·kg -1 curcumin), group MC and control (ig of 0.9% saline). After treating the mice for 7 days, all the mice except control group received intraperitoneal injection of MC at a dose of 38.11 μg·kg -1 (0.6 LD_ 50). 3 h later, all the animals were sacrificed then the livers were processed for the estimation of ALT, AST, LDH, ALP, GST, SOD and MDA levels. Results Levels of liver homogenate ALT,LDH and GST in group MC were (198.65±14.11) U·L -1, (597.47±124.95) U·L -1 and (85.23±27.28) kU·g -1 Pro respectively, significantly higher than those of the control, P0.05. The levels of ALT, LDH and GST in group curcuma were (178.40±13.46) U·L -1, (422.18±105.53) U·L -1 and (55.86±13.39) kU·g -1.Pro and in group curcumin were (168.41±16.13) U·L -1, (220.60±117.36) U·L -1 and (54.22±23.87) kU·g -1 Pro respectively, markedly lower than those of group MC, P0.05. A significant increase in MDA level and decrease in SOD activity were found in group MC. Prophylactic administration of curcuma or curcumin resulted in a significant amelioration in the changes of SOD and MDA levels induced by MC, P0.01. Conclusion Hpatic anti-oxidative abilities can be enhanced by curcuma and curcumin,which might act as chemopreventive agents for protection of liver injury induced by MC.
【CateGory Index】: R285
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