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《Chinese Pharmacological Bulletin》 2006-07
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Expression ofα-smooth muscle actin in adrnomedullin knockout mice with unilateral ureteral obstruction and treated by valsartan

XUQing-you1,DING Ying-jun1,ZHULi1,LIULi-jian1,LIULi1,ZHAO Yu-yong1,SHIMOSAWA Tatsuo2,FUJITA Toshiro2(1.College ofIntegrated Traditional and Western Medicine,Hebei MedicalUniversity,Shijiazhuang050091,China;2.Dept ofNephrology and Endocrinology,Tokoy University,Tokoy,Japan)  
Aim To observe the expression ofα-smoothmuscle actin(α-SMA) in adrenomedullin knockoutmice with unilateral ureteral obstruction(UUO) andthe effectofvalsartan.Methods Renal interstitial fi-brosis animals were made with UUO、α-SMA and theexpression of mRNA were examined in adrnomedullinknockout(AMKO) mice and wild type(WT) mice byimmunohistochemistry and RT-PCR.Results The ex-pression ofα-SMA in UUO groups were up-regulatedsignificantly compared with sham group(P0.01),specically in AMKO group.Valsartan has the effect indown-regulating its over-expression.Conclusion Tu-bular epithelial-myofibroblast transdifferentiation wasinduced by UUO and over-expression in AMKO mice.Valsatan has a role to inhibit it partly.
【Fund】: 国家留学基金管理委员会资助项目(2001年)
【CateGory Index】: R96
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