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《Chinese Pharmacological Bulletin》 2007-02
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Expression of adrenomedullin in SD rats with unilateral ureteral obstruction and effect of valsartan and safflower

XU Qing-you, DING Ying-jun, HAN Lin, BU Tong-wen, JIA Xiao-min, ZHU Li, WANG Yue-hua, LIU Li-jian,ZHAO Yu-yong (College of Integrated Traditional and Western Medical, Hebei Medical University, Shijiazhuang, 050091,China)  
Aim To investigate the expression of Adrenomedullin in obstructive nephropathy induced by unilateral ureteral obstruction (UUO) and treated with Valsartan and safflower. Methods SD rats were used to get the UUO and treated by Valsartan(10 mg·kg-1·d-1) and safflower(0.4 g·kg-1·d-1), the ligated kidneys were got at the 14th day after operation. The expression of adrnomedullin was determined with immunohistochemistry and in situ hybridization. Results The positive area and density of adrenomedullin was down-regulated in obstructive kidneys induced by UUO markedly and up-regulated by Valsartan and safflower. Conclusions Valsartan and safflower might inhibit the renal interstitial fibrosis through the adrnomedullin.
【Fund】: 国家留学基金资助项目;; 河北省科技厅攻关资助项目(No0520611034D-7)
【CateGory Index】: R692
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