Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Pharmacological Bulletin》 2007-02
Add to Favorite Get Latest Update

Effects of TGP on functions of fibroblast-like synoviocytes under the stimulation of IL-α in CIA rats

CHANG Yan,WEI Wei,ZHANG Lei,XU Hong-mei (Institute of Clinical Pharmacology Anhui Medical University,Key Laboratory of Antiinflammatory and Immunopharmacology in Anhui Province,Key Laboratory of Research and Development of Chinese Medicine in Anhui Province,Hefei 230032,China)  
Aim To study effects of TGP on fibroblast-like synoviocytes(FLS) under the stimulation of rIL-1α and investigate the mechanism. Methods CIA was induced in male Sprague-Dawley rats immunized with chicken type Ⅱ collagen in Freund′s complete adjuvant; rIL-1α-induced FLS proliferation was observed by 3-(4,5-dimethylthiazol-2-yl) 2,5-diphenyltetrazolium bromide(MTT) assay. Levels of PGE2 and cAMP were determined by radioimmunoassay(RIA). Results Levels of PGE2 and cAMP produced by FLS under the stimulation of rIL-1α(0.01、0.1、1、10 μg·L-1) and rIL-1α(3、6、12、24 h)were elevated. TGP(2.5、12.5、62.5、125、250 mg·L-1) inhibited the proliferation and decreased the level of PGE2 and increased the level of cAMP. Conclusion Under the stimulation of rIL-1α in different time and different concentration, levels of PGE2 and cAMP produced by FLS were elevated significantly. TGP inhibited the proliferation and decreased the level of PGE2 and increased the level of cAMP in vitro.
【Fund】: 国家自然科学基金资助项目(No30271606 No30572356);; 安徽省自然科学基金资助项目(No050430903)
【CateGory Index】: R285
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Ling-ling,WEI Wei,WANG Qing-tong,CHEN Jing-yu,CHEN Yin,WU Hua-xun (Institute of Clinical Pharmacology,Anhui Medical University,Hefei 230032,China);Regulatory effects of Paeoniflorin on G protein-coupled signaling of synoviocytes in collagen-induced arthritis rats[J];Chinese Pharmacological Bulletin;2008-03
2 LU Jing-tao,SUN Wu-yi,LIU Hao,LI Xiang,WEI Wei(Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory of Anti-inflammatory andImmunopharmacology in Anhui Province,Key Laboratory of R and D of Chinese Medicine in Anhui Province,Engineering Research Center of Anti-inflammatory and Immunodrugs,Hefei 230032,China);Effects of total glucosides of paeony on protein expression of NF-kappa B and TGF-β1 in hepatic tissue of rats with immunological hepatic fibrosis[J];Chinese Pharmacological Bulletin;2008-05
3 CHEN Jing-yu,WU Hua-xun,CHEN Yin,ZHANG Ling-ling,WEI Wei(Institute of Clinical Pharmacology,Anhui Medical University;Anhui Key Laboratory of Antiinflammatory andImmunopharmacology;Anhui Key Laboratory of Research and Development of Chinese Medicine;Engineering Technology Research Center of Antiinflammatory and Immunodrugs in AnHui Province,Hefei 230032,China);Expression of GRKs in synovial tissue from rats with collagen-induced arthritis and the effect of total glucosides of paeony[J];Chinese Pharmacological Bulletin;2008-06
4 LI Chuan-ying,WANG Chun,WEI Wei(Institute of Clinical Pharmacology,Anhui Medical University,Anhui Key Laboratory of Anti-inflammatory andImmunopharmacology,Anhui Key Laboratory of Research and Development of Chinese Medicine,Anhui Engineering Technology Research Center of Anti-inflammatory and Immune Drugs,Hefei 230032,China);Effects and sectional mechanisms of total glucosides of paeony on mice with chronic dermatitis-eczema[J];Chinese Pharmacological Bulletin;2008-10
5 TANG Li-qin1,2,WEI Wei1,WANG Xiao-yu1(1.Institute of Clinical Pharmacology,Key Laboratory of Anti-inflammatory and Immune Pharmacology of EducationMininstry and Anhui Province,Anhui Medical University,Hefei 230032,China;2.Dept of Pharmacy,the Affiliated Anhui Provincial Hospital,Anhui Medical University,Hefei 230001,China);Effects of GCS on functions of fibroblast-like synoviocytes under the stimulation of IL-1α in AA rats[J];Chinese Pharmacological Bulletin;2009-01
6 ZHANG Pei,ZHANG Jing-Jing,SU Jing,QI Xiang-min,WU Yong-gui(Dept of Nephrology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China);Effect of total glucosides of paeony on the expression of Nephrin and its mechanism in the kidney of diabetic rats[J];Chinese Pharmacological Bulletin;2009-03
7 GUO Xiao-rong,DAI Xing,ZHANG Ling-ling,WEI Wei(Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory of Anti-inflammatory and Immunopharmacology ofEducation Ministry,Anhui Engineering Technology Research Center of Anti-inflammatory and Immunopharmacy,Hefei 230032,China);Effects of paeoniflorin on the human fibroblast-like synoviocytes under the stimulation of rhIL-1α[J];Chinese Pharmacological Bulletin;2009-04
8 DAI Xing,GUO Xiao-rong,CHANG Yan,WEI Wei(Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory of Anti-inflammatory and Immunopharmacology ofEducation Ministry,Anhui Engineering Technology Research Center of Anti-inflammatory and Immunodrugs,Hefei 230032,China);Influence of cryopreservation on the survival of fibroblast-like synoviocytes[J];Chinese Pharmacological Bulletin;2009-06
9 Zou Wei1,Xu Hongmei2 1.Pharmaceutical Preparation Section,People's Hospital of Huangshan City,Huangshan,Anhui,245000,China;2.Department of Pharmaceutical Engineering,Hefei Industrial University,Hefei,Anhui,230000,China;Effects of troxerutin on levels of prostaglandins E2,interleukin-1β and tumor necrosis factor-α secreted by synoviocytes of rats with adjuvant arthritis[J];Medical Journal of National Defending Forces in Southwest China;2011-01
10 Ling Lin,Chen Jingyu,Bao Min,et al(Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory of Anti-inflammatory and Immunopharmacology of Education Ministry of China,Anhui Key Laboratory of Research and Development for Chinese Medicine,Anhui Engineering Research Center of Anti-inflammatory and Immune Drugs,Hefei 230032);Comparison of effects of paeoniflorin microemulsion and paeoniflorin in rats with adjuvant arthritis[J];Acta Universitatis Medicinalis Anhui;2011-03
【Citations】
Chinese Journal Full-text Database 4 Hits
1 YAN Shang-Xue, WEI Wei, ZHANG Ling-Ling, WANG Ni-Ping, WANG Hua,WU Cheng-Yi (Institute of Clinical Pharmacology, Anhui Medical University,Hefei 230032);Effect of melatonin on collagen-induced arthritis in mice[J];Chinese Pharmacological Bulletin;2004-05
2 WU Hong 1,2 ,SONG Li-hua1,WEI Wei1 (1.Institute of Clinical Pharmacology,Anhui Medical University, Key Laboratory of Antiinflammatory-immunopharmacology in Anhui Province,Key Laboratory of Reasearch & Development of Chinese Medicine in Anhu Province,Hefei 230032, China; 2.Anhui College of Traditional Chinese Medicine, Hefei 230031, China);G protein-coupled receptor and drug targets for therapy in rheumatoid arthritis[J];Chinese Pharmacological Bulletin;2006-09
3 Jia Xiaoyi, Wei Wei, Zheng Yongqiu, et al (Institute of Clinical Pharmacology, Anhui Medical University,Key Laboratory of Anti-inflammatory and Immunopharmacology in Anhui Province,Hefei 230032);Effect of total glucosides of paeony on Bbcl-2,Bax expression in rats of synovial tissue with collagen-induced arthritis[J];Acta Universitatis Medicinalis Anhui;2006-02
4 ZHU Lei,WEI Wei~(*),ZHENG Yong-qiu(Institute of Clinical Pharmacology,Anhui Medical University,Hefei 230032,China);Effect and mechanism of action of total glucosides of paeony on synoviocytes from rats with collagen-induced arthritis[J];Acta Pharmaceutica Sinica;2006-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Yuan-chao,SUN Hong-sheng,PAN Zheng-lun,LI Ming (Department of Rheumatology and Immunology,Shandong Provincial Hospital,Shandong University,Jinan 250021,China);Research progress of total glucoside of paeony in rheumatic disease[J];World Clinical Drugs;2010-08
2 Xing ShiTong,et al;Study on effects of balance antioncoti lavage fluids on rabbit articular cartilage[J];Zhejiang Clinical Medical Journal;2008-10
3 XIAO Kun~* (Department of Clinical Medicine,Peking Union Medical College,Beijing 100730,China);Application of Total Glucosides of Peony in Autoimmune Diseases[J];Chinese Journal of Allergy and Clinical Immunology;2008-01
4 ZHENG Lin-ying1,PAN Jing-qiang2*,L Jun-hua3 (1.Guangzhou Hospital of Traditional Chinese Medicine,Guangzhou 510130,China;2.Guangzhou Institute of Traditional Chinese Medicine & Materia Medica,Guangzhou 510130,China;3.College of Pharmacology,Jinan University,Guangdong Guangzhou 510632,China);Effects of Total Glucosides of Paeong on Insulin Sensitivity and Blood Lipid in Insulin Resistant Rats Induced by High Fat Diet[J];Lishizhen Medicine and Materia Medica Research;2008-02
5 Yang Jingfeng1 Zhao Tiancai1 Wei Hiumin1 Wei Peifeng1 An Peng2 Zheng Bo3(1.Shaanxi College of Traditional Chinese Medicine,Xianyang,Shaanxi,712046;2.TCM Dept.of Second Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi,710004;3.Chongqing Three Gorges Medical College,Chongqing 404020);Effect of Jia wei shao gan fu zi tang on content of IL-6,IL-10 of ICA Rats[J];Journal of Shaanxi College of Traditional Chinese Medicine;2010-01
6 CHEN Jing-yu,WU Hua-xun,CHEN Yin,ZHANG Ling-ling,WEI Wei(Institute of Clinical Pharmacology,Anhui Medical University;Anhui Key Laboratory of Antiinflammatory andImmunopharmacology;Anhui Key Laboratory of Research and Development of Chinese Medicine;Engineering Technology Research Center of Antiinflammatory and Immunodrugs in AnHui Province,Hefei 230032,China);Expression of GRKs in synovial tissue from rats with collagen-induced arthritis and the effect of total glucosides of paeony[J];Chinese Pharmacological Bulletin;2008-06
7 Wang Xiaoyu,Wei Wei,Tang Liqin,et al(Institute of Clinical Pharmacology, Anhui Medical University; Key Laboratory of Antiinflammatory-Immunopharmacology in Anhui Province;Key Laboratory of R&D of Chinese Medicine in Anhui Province,Hefei 230032);Effect of paeoniflorin on peritoneal macrophage from rats of adjuvant-induced arthritis[J];Acta Universitatis Medicinalis Anhui;2007-02
8 Wu Huaxun,Chen Jingyu,Yan Shangxue,et al(Institute of Clinical Pharmacology,Anhui Medical University;Anhui Key Laboratory of Antiinflammatory andImmunopharmacology;Anhui Province Key Laboratory of Research and Development of Chinese Medicine;Anhui Engineering Technology Research Center of Anti-inflammatory and Immunodrugs,Hefei 230032);The expression of beta-arrestin 1 and beta-arrestin 2 in the synovium of collagen-induced arthritis rats[J];Acta Universitatis Medicinalis Anhui;2008-02
9 Yuan Fang,Wang Liwen,Wei Wei(Institute of Clinical Pharmacology,Anhui Medical University;Key Laboratory of Anti-inflammatory andImmunopharmacology,Ministry of Education; Anhui Key Laboratory of Anti-inflammatory and Immunopharmacology;Anhui Engineering Technology Research Center of Anti-inflammatory and Immune Drugs,Hefei 230032);Effects of recombinant human interleukin-1β on functions of peripheral blood mononuclear cells from healthy adults and the role of paeoniflorin[J];Acta Universitatis Medicinalis Anhui;2009-02
10 ZHANG Lei,WEI Wei,CHANG Yan,XU Hong-mei (Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory of Antiinflammatory and Immunopharmacology in Anhui Province,Key Laboratory of Research and Development of Chinese Medicine in Anhui Province,Hefei 230032,China);Effects of TNF-α versus total glucosides from paeony on functions of synovial cells of CIA rats[J];Chinese Journal of New Drugs;2007-07
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZOU Wei,XU Hong-mei,WANG Yu-hua(Pharmaceutical Preparation Section,Huangshan People's Hospital,Anhui Huangshan 245000,China);Effects of Troxerutin on Hemorheological Parameters in Rats with Adjuvant Arthritis[J];Journal of Anhui Traditional Chinese Medical College;2008-06
2 JIN Hui ling,ZHANG Ru zhi,YU Qi bin (Department of Dermatology,Affiliated Hospital of Bengbu Medical College,Anhui 233004 ,China);Model of chronic dermatitis-eczema in mice[J];Journal of Bengbu Medicinae College;2002-03
3 Huang Qingchun et al( Guangzhou General Hospital of Army, Guangzhou University of TCM );Comparison Research of Pathological Effect of Tongbiling, Tripterygium WifordiiHook and Sinomenine on Synovial Tissue in Experimental Arthritis Rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2003-01
4 LI Jing yi 1, WU Yu zhang 1, FANG Yong fei 2, WANG Yong 2, ZHANG Jing bo 1, LI Yang 1 ( 1Institute of Immunology, College of Medicine; 2Department of Traditional Chinese Medicine, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Expressions of CD28 and CTLA-4 in peripheral blood and synovial fluid lymphocytes in patients with rheumatoid arthritis and the significance[J];Acta Academiae Medicinae Militaris Tertiae;2004-06
5 WANG Yong, ZHONG Bing, FANG Yong-fei, LI Jing-yi, AI Jiu-song (Department of Traditional Chinese Medicine, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Effects of sinomenine on inflammatory cytokines and anti-cyclic citrullinated peptide antibody in patients with rheumatoid arthritis[J];Acta Academiae Medicinae Militaris Tertiae;2005-15
6 JIANG Jian-ping, YANG Tie-cheng, HOU Fan-fan, ZHU Zhi-gang (Departments of Nephrology and Orthopaedics, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China);Isolation and culture of human joint type-A and type-B synovial cells[J];Journal of First Military Medical University;2001-01
7 HU Yong-hong*,WENG Geng-min,LU Fu-er,LAI Xian-yang,ZHANG Ming-min,LIU Pei-lin.*Institute of Integrated Traditional Chinese and Western Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Experimental investigation on triptolide induced apoptosis of synoviocytes in collagen induced arthritis rat[J];Chinese Journal of Rheumatology;2004-03
8 HU Yong-hong*, ZENG Ke-qin, ZHANG Ming-min, TU Sheng-hao, LAI Xian-yang, ZHANG Wei-Shen. *Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Effects of triptolide on the expression and activity of nuclear factor κB in synovium of collagen-induced arthritis rats[J];Chinese Journal of Rheumatology;2004-09
9 SUN Tie-zheng, Lǚ Hou-shan. Arthritis Clinic and Research Center, People′s Hospital, Peking University, Beijing 100044, China;Expression regulation modulation of intercellular adhension molecular-1 and vascular cell adhension molecule-1 induced by interleukin-1β and tumor necrosis factor-α on fibroblast-like synoviocytes of rheumatoid arthritis[J];Chinese Journal of Rheumatology;2005-03
10 MIN Wei-qi*, WEI Qin, Li Hong-yu, ZHANG Zhen-chun,WU Li-jun, YUAN Guo-hua, DOU Cun-rui, SHI Gui-ying. *Department of Rheumatology, Heze City Hospital, Shandong 274031, China;A clinical study of total glucosides palony in the treatment of rheumatoid arthritis: a multi-center trial[J];Chinese Journal of Rheumatology;2005-08
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Yuan-chao,SUN Hong-sheng,PAN Zheng-lun,LI Ming (Department of Rheumatology and Immunology,Shandong Provincial Hospital,Shandong University,Jinan 250021,China);Research progress of total glucoside of paeony in rheumatic disease[J];World Clinical Drugs;2010-08
2 WANG Chun,WEI Wei,YANG Zhao-yi,NIE Xin-xin(Institute of Clinical Pharmacology,Anhui Medical University,Anhui Key Laboratory of Antiinflammatory-immunopharmacology,Anhui Engineering Technology Research Center of Anti-inflammatory and Immune Drugs,the key Laboratory of Antiinflammatory and Immunopharmacology,Ministry of Education,China,Hefei 230032,China);Studies on absorption kinetics of paeoniflorin microemulsion in rat's intestines[J];Chinese Pharmacological Bulletin;2009-02
3 ZHANG Pei,ZHANG Jing-Jing,SU Jing,QI Xiang-min,WU Yong-gui(Dept of Nephrology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China);Effect of total glucosides of paeony on the expression of Nephrin and its mechanism in the kidney of diabetic rats[J];Chinese Pharmacological Bulletin;2009-03
4 GUO Xiao-rong,DAI Xing,ZHANG Ling-ling,WEI Wei(Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory of Anti-inflammatory and Immunopharmacology ofEducation Ministry,Anhui Engineering Technology Research Center of Anti-inflammatory and Immunopharmacy,Hefei 230032,China);Effects of paeoniflorin on the human fibroblast-like synoviocytes under the stimulation of rhIL-1α[J];Chinese Pharmacological Bulletin;2009-04
5 LI Na1,2,WU Lei1,SU Yun-ming2,CHEN Xi-jing11Key Laboratory of Drug Metabolism & Pharmacokinetics,China Pharmaceutical University,Nanjing 210009;2Heilongjiang University of Chinese Medicine,Harbin 150040,China;Pharmacokinetics of paeoniflorin in acute liver injury rats induced by CCl_4[J];Journal of China Pharmaceutical University;2009-01
6 LI Zhenbin1,WANG Zhiqiang1,2,GONG Caixia3,GENG Lifen1,HUI Nailing1,ZHU Jianjun1(1.Bethune International Peace Hospital of PLA,Shijiazhuang 050082,China;2.Graduate Academy of Hebei Medical University,Shijiazhuang 050017,China;3.Shijiazhuang Ping'an Hospital,Shijiazhuang 050051,China);Toxicity-reducing and Action-enhancing Effects of Total Glucosides of Paeony on Tripterygium Glycosides in Treating Lupus Nephritis[J];Traditional Chinese Drug Research & Clinical Pharmacology;2009-06
7 CAO Bi-yin1,SUN Xue1,YANG Ya-ping1,2,KONG Yan2,LIU Chun-feng1,2 (1. Dept of Neurology,the Second Affiliated Hospital of Soochow University,Suzhou Jiangsu 215004,China;2. Institute of Neuro-science,Soochow University,Suzhou Jiangsu 215123,China);Paeoniflorin inhibited the calcium influx via down-regulating the expression of acid sensing ion channel 1a on PC12 cells treated with acidosis[J];Chinese Pharmacological Bulletin;2010-01
8 CAO Bi-yin1,KONG Yan2,XU Zhuan2,YANG Ya-ping1,2,LIU Chun-feng1,2 (1.Dept of Neurology,the Second Affiliated Hospital,2.Laboratory of Aging and Neurons Diseases,Institute of Neuroscience,Soochow University,Suzhou Jiangsu 215004,China);Protective effects of paeoniflorin on dopaminergic neurons in brain slice of substantia nigra treated with 1-methyl-4-phenylpytidinium[J];Chinese Pharmacological Bulletin;2010-02
9 WANG Jun,MA Xiao-ling,LIU Wei-bei,CI Chao,CHANG Xiao-li,JI Bi-hua Department of Dermatology,Yijishan Hospital of Wannan Medical College,WuHu 241001,Anhui,China;Observation of therapeutic effect of mizolastine and total glucosides of paeony capsule on chronic idiopathic urticaria[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2010-01
10 TANG Li-qin1,2,WEI Wei1,LIU Sheng2,ZHANG Shan-tang2,WANG Xiao-yu1(1 Institute of Clinical Pharmacology,Key laboratory of Anti-inflammatory and ImmunePharmacology in Anhui Province,Anhui Medical University,Hefei 230032,China;2 Department of Pharmacy,Affiliated Anhui Provincial Hospital,Anhui MedicalUniversity,Hefei 230001,China);Effects of catechin on functions of fibroblast-like synoviocytes under the stimulation of IL-1α in adjuvant arthritis rats[J];Chinese Journal of New Drugs;2010-03
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 SUN Wu-yi,ZHANG Ling-ling,WU Li,WANG Ni-ping,WANG Hua,YUE Li,ZHANG Yun-fang, WEI Wei (Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032,C hina);Therapeutic effects of recombinant human interleukin 1 receptor antagonist on type Ⅱ collagen-induced arthritis rats[J];Chinese Pharmacological Bulletin;2005-01
2 WEI Wei, XU Xing Ming 1, SHEN Yu Xian, DING Chang Hai, ZHANG An Ping, XU Shu Yun (Institute of Chinical Pharmacology, Anhui Medical University, Hefei 230032);Effects of melatonin on peripheral blood lymphocyte proliferation from patients with rheumatoid arthritis and G protein coupled cAMP signal transduction[J];CHINESE PHARMACOLOGICAL BULLETIN;1998-06
3 J IN Yong,LI Jun,ZHANG Yun Fang,LI Chang Yu,XU Shu yun (Institute of Clinical Pharmacology, Anhui Medical University,Hefei 230032,China);The therapeutic action of actarit in type Ⅱ collagen-induced arthritis mice and its mechanism[J];Chinese Pharmaceutical Journal;2001-12
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved