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《Chinese Pharmacological Bulletin》 2007-06
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Effect of total glucosides of paeony on the expression of intercellular adhesion molecule-1 and transforming growth factorⅠ protein in the kidney in experimental diabetes

YUAN Liang, WU Yong-gui, HAO Li, LIANG Chao, DONG Jing, REN Ke-jun, ZHANG Wei, FANG Fang(Dept of Nephrology, the First Affliated Hospital, Anhui Medical University, Hefei 230022, China)  
Aim To investigate the effect of total glucosides of paeony (TGP) on the expression of intercellular adhesion molecule-1 (ICMA-1) and transforming growth factor 1 (TGF 1) protein in the kidney in experimental diabetes. Methods Diabetes was induced with streptozotocin in Sprague-Dawley rats. TGP (50, 100, 200 mg·kg-1·d-1) was orally administered once a day for 8 wk to rats. Results Elevated urinary albumin excretion rate (AER) was markedly attenuated by TGP treatment with 50, 100 and 200 mg·kg-1. Increased malondialdehyde (MDA) level was only significantly reduced by TGP treatment with 200 mg·kg-1. Elevated glomerular volume was significantly attenuated by TGP treatment with 50, 100 and 200 mg·kg-1, and increased indices for tubulointerstitial injury were only ameliorated by TGP treatment with 100 and 200 mg·kg-1. Western blot analysis noted that the expression of 1 type Ⅳ collagen protein was increased 2.7 -fold in the kidney in diabetic rats, TGP treatment with 50, 100 and 200 mg·kg-1 could reduced increased expression of 1 type Ⅳ collagen protein by 47.9 %, 60.4 % and 72.9 %. The expression of ICAM-1 and TGF 1 protein in the kidney were significantly increased in diabetic rats, which were all significantly inhibited by TGP treatment. Conclusion Our data suggest that TGP treatment ameliorates early renal injury via the inhibition of oxidative stress and overexpression of ICAM-1 and TGF-1 in renal tissue in diabetic rats.
【Fund】: 安徽省自然科学基金资助项目(No070413100);; 安徽省教育厅自然科学基金资助项目(No2006KJ316B)
【CateGory Index】: R285.5
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