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《Chinese Pharmacological Bulletin》 2007-10
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Effects of Triptolide on HL-60 Cell in vitro and in vivo

YU Ping-li1,CHEN Yuan-zhong1,XU Jian-hua2, WU Yong1,CHEN Xian-ling1(1.Fujian Institute of Hematology;Union Hospital, Fujian Medical University, Fuzhou 350001,China;2.College of Pharmacy,Fujian Medical University,Fuzhou 350004,China)  
Aim To study the effects of Triptolide (TPL) on HL-60 cells in vitro and in vivo.Methods MTT was used to examine the effects of TPL on proliferation of HL-60 cells;TUNEL assay was used to detect apoptotic cells.The effect of TPL on xenograft growth of HL-60 cells was evaluated by tumor inhibition rate.Results In vitro TPL inhibited the proliferation and induced apoptosis of HL-60 cells in a dose-dependent manner.In vivo TPL inhibited xenograft growth of HL-60 cells with the highest inhibition rate of 53.5%.Conclusion TPL is able to inhibit the proliferation of HL-60 cells and induce apoptosis of HL-60 cells in vitro and in vivo.
【Fund】: 福建省重点建设高校资助项目(NoXZ04001);; 福建省重大专项前期研究课题(NoYZ20051008)
【CateGory Index】: R285.5
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