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《Chinese Pharmacological Bulletin》 2008-01
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Research advance of arylamine N-acetyltransferase

GAO Shi-yong,JI Yu-bin(Postdoctoral Research Station,Institute of Materia Medica,Life Science and Environment Science ResearchCenter of Harbin Commerce University,Harbin 150076,China)  
Arylamine N-acetyltransferase(NATs)is one of phase Ⅱ drug-metabolizing enzymes,which is very important in drug metabolizing and detoxification.It may become a new target for studying pharmacological effects.The study on NATs is hitherto its crystal structure or polymorphisms among different species,different ethnicity,same species,and same ethnicity.However,the study on its physiological and pharmacological effects is unwontedly reported.In the paper the research work on NATs is summarized from the following aspects:the structure,carcinogenic mechanism,endogenous activities,inhibitor,substitute products,metabolic kinetics,polymorphism and relation with diseases,and detected methods of NATs.
【Fund】: 国家自然科学基金资助项目(No30400591);; 黑龙江省自然科学基金资助项目(NoD200505 D-2004-13);; 黑龙江省教育厅骨干教师创新能力资助计划(2006);; 哈尔滨市青年基金资助项目(No2004AFQXJ035)
【CateGory Index】: R341
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【References】
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1 JI Yu-bin1,2,GAO Shi-yong1,2,JI Chen-feng1,2,ZOU Xiang1,2(1.Postdoctoral Programme,Institute of Materia Medica,Center of Research and Development on Life Sciences andEnviroment Sciences of Harbin University of Commerce;2.Engineering Research Center ofNatural Anticancer Drugs,Ministry of Education.Harbin 150076,China);Effects of solanine on kinetic constants of NATase in HepG_2 cells[J];Chinese Pharmacological Bulletin;2008-09
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1 MO Xiao-mei, LI Jing, GENG Mei-yu (Molecular Pharmacology Lab, Medicine College, Ocean University of China,Qingdao Shandong 266003,China)[FL(2K2];DNA topoisomerase and antitumor[J];Chinese Pharmacological Bulletin;2007-01
【Co-citations】
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1 ZHANG Yan-li1,YANG Yi-dong1,LI Zu-qiang2,FANG Tian-tian1,LIU Ya-min1,QING Chen1(1.The Key Laboratory of Pharmacology for Natural Products in Yunnan Province Kunming Medical College,Kunming 650031,China;2.Research Center,School of Chemistry and Material Engineering,Yunnan University,Kunming 650091,China);Antitumor activity of santamarin and its effect on topoisomerase[J];Chinese Pharmacological Bulletin;2007-10
2 ZHANG Jia-jie,WANG Guang-fa,WU Shu-guang(School of Pharmaceutical Sciences,Southern Medical University,Guangzhou 510515,China);Interactions of anticancer drugs and miRNA targets[J];Chinese Pharmacological Bulletin;2008-11
3 TAN Hui-xin(Pharmacy Department of the Forth Affiliated Hospital to Harbin Medical University,Harbin 150001,China);Research progress on topoisomerase Ⅰ inhibitors[J];Chinese Pharmacological Bulletin;2009-04
4 ZHOU Qing-feng1,LI Ming-yue2,NA Guang-shui3,LI Cheng-wei1(1.Dept of Life Science and Technology,Shangqiu Normal College,Shangqiu Henan 476000,China;2.School of Life Science and Technology,China Pharmaceutical University,Nanjing 210009,China;3.National Marine Environmental Monitoring Center,Dalian Liaoning 116023,China);Progress in research of antitumor mechanisms of marine polysaccharides[J];Chinese Pharmacological Bulletin;2009-08
5 MA Yun-tong (Editorial board,Xi'an University of Arts and Science,Xi'an 710065,China);DNA Damage,Repair and Checkpoint Response Mediated by Topoisomerase Ⅰ Inhibitor[J];Journal of Xi'an University of Arts & Science(Natural Science Edition);2010-01
6 LI Yan-mei1,2,SHEN Xiao-yan1 (1. Laboratory of Pharmacology and Toxicology,School of Pharmaceutical Sciences, Sun Yat-Sen University,Guangzhou 510275,China;2. Bio-Pharmacy Technology of R & D Center,Institutes of Life & Health Engineering,Jinan University,Guangzhou 510632,China);Progress in the study of G-quadruplex telomerase inhibitors[J];Chinese Pharmacological Bulletin;2010-01
7 LU Li,PENG Fang. ( College of Pharmacy,Dali Universi- ty,Dali 671000,China);Advances in Targeted Anti-tumor Drugs[J];Medical Recapitulate;2010-13
【Co-references】
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1 SUN Jun,LI Yan(Dept of Gastroenterology,Second Clinical College,China Medical University,Shenyang 110004,China);Effects of curcumin on expression of HIF-1α in human hepatocellular carcinoma BEL-7402 cells[J];Chinese Pharmacological Bulletin;2006-11
2 LIU Chun-yu1, GU Zhen-lun2, DU Chong-min1,YANG Ji-cheng3 (1.College of Pharmacy, Soochow University; 2.Shuzhou Institute of Chinese Meteria Medica; 3.Dept of Cellular and Molecular Biology,Soochow University, Suzhou Jiangsu 215123,China);Effect of flavonoids of Astragalus complanatus on SMMC7721 human liver caner subcutaneous transplanting tumor in nude mice[J];Chinese Pharmacological Bulletin;2007-06
3 FAN Chang-long1,LUAN Yan1,CHEN Yan1,ZHANG Jun1,ZHANG Wan1,YANG Bao-feng1,2,DONG De-li1,2(1.Dept of Pharmacology,Harbin Medical University,2.Bio-pharmaceutical Key Laboratory of Heilongjiang Province,Harbin 150086,China);Effects of chlorzoxazone on HepG2 tumor cells[J];Chinese Pharmacological Bulletin;2007-09
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6 Yu-bin JI1,2, Shi-yong GAO1,2 (1Postdoctoral Research Station of the Institute of Materia Medica, Center for Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China) (2MOE Engineering Research Center of Natural Anticancer Drugs, Harbin University of Commerce, Harbin 150076, China);Arylamine N-acetyltransferases: a new inhibitor of apoptosis in HepG2 cells[J];浙江大学学报B(生物医学、生物工程版)(英文版);2008-09
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1 GAO Shi-yong1,2,LANG Lang1,2,ZOU Xiang1,2,JI Chen-feng1,2,JI Yu-bin1,2,MA Qiang1,2,YUE Lei1,2,QU Zhong-yuan1,2,SHANG Ming1,2(1.Post-doctoral Research Station,Institute of Materia Medica,Center of Research and Development on Life Sciences and Environment Sciences of Harbin University of Commerce,Harbin 150076,China; 2.MOE Engineering Research Center of Natural Anticancer Drugs,Harbin University of Commerce,Harbin 150076,China);Effects of humulon on kinetic constants of NAT1 in SGC-7901 cells[J];Chinese Traditional and Herbal Drugs;2010-06
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