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《Chinese Pharmacological Bulletin》 2008-08
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Resveratrol's effect on acute phases of focal cerebral ischemic injury in mice

DONG Wen-peng,ZHANG Xiang,GAO Da-kuan,ZHEN Hai-ning,LI Bin,CAO Lei,LIN Hong,HUO Jun-li(Institute of Neurosurgery,Xijing Hospital,Fourth Military Medical University PLA,Xi'an 710032,China)  
Aim To discuss the influence of resveratrol on acute phases of focal cerebral ischemic injury in mice and possible mechanisms.Methods Ninety Balb/c healthy male mice,weighting 18~22 g,were randomly divided into three groups:resveratrol group,fenofibrate group and ischemia group.There were thirty mice in each group.The ischemic model of mice was induced with an 8/0 nylon monofilament coated with silicone hardener mixture via the internal carotid artery.24 hours after reperfusion,the infarct area was shown by 2,3,5-triphenyl tetrazolium chlorid(TTC)staining;Evans blue staining was used for showing the damage of blood brain barrier and the express of peroxisome proliferator activated receptor(PPAR)alpha was shown by RT-PCR.Results The infarct volume in resveratrol group and fenofibrate group were lower thanischemia group〔(43.80±5.31)mm3,(45.57±5.63)mm3 vs(63.87±9.33)mm3,P0.01)〕.In resveratrol group and fenofibrate group,the extent and quality of Evans blue extravasation were reduced compared with ischemia group〔(58.66±4.65)mm3,(78.72±5.78)mm3 vs(102.06±6.07)mm3,P0.01〕 and(6.40±0.92)μg·g-1,(12.47±1.24)μg·g-1 vs(15.25±1.51)μg·g-1,P0.01)〕,PPARα mRNAs were prominently expressed compared with ischemia group(0.893±0.028,1.117±0.042 vs 0.467±0.013,P0.01).Conclusion The study suggests that resveratrol has protective effects against acute ischemic stroke,which could be attributed to its property increasing PPARα.Thus,resveratrol may be a potential agent for the treatment of neuronal injury associated with stroke.
【Fund】: 国家自然科学基金面上资助项目(No30672663)
【CateGory Index】: R285
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