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《Chinese Pharmacological Bulletin》 2008-11
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Appliance of PK/PD modeling in traditional chinese medicine research

SHU Yun,LI Lian-da(China Academy of Chinese Medical Sciences,Xiyuan Hospital,Beijing 100091,China)  
Pharmacokinetic-pharmacodynamic(PK/PD)modeling,as an available tool accounting for the interrelated dynamic connection between the dosage and efficiency of drugs,plays an important role in the field of studying the mechanism and optimizing the clinical administration of traditional Chinese medicine(TCM).Based on the general illustration on the foregoing application of PK/PD modeling,the present work investigates the involving challenges in the field,such as the selection of the target chemical composition and effect mark.In accordance with the unique properties of TCM,further,the related suggestions,mainly focusing on determining the substances based on the effect and establishing the multi-index appraise system,are put forward as reference for the following research work.
【Fund】: 中医药科学技术研究专项资助项目(No06-07ZQ16)
【CateGory Index】: R28
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