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《Chinese Pharmacological Bulletin》 2009-01
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Effects of GCS on functions of fibroblast-like synoviocytes under the stimulation of IL-1α in AA rats

TANG Li-qin1,2,WEI Wei1,WANG Xiao-yu1(1.Institute of Clinical Pharmacology,Key Laboratory of Anti-inflammatory and Immune Pharmacology of EducationMininstry and Anhui Province,Anhui Medical University,Hefei 230032,China;2.Dept of Pharmacy,the Affiliated Anhui Provincial Hospital,Anhui Medical University,Hefei 230001,China)  
Aim To study effects of glucosides of chaenomeles speciosa(GCS) on fibroblast-like synoviocytes(FLS) under the stimulation of recombinant rat interleukin-1-alpha(rIL-1α) and investigate the mechanism.Methods Complete Freund's adjuvant(FCA) was used to induce adjuvant arthritis(AA) in rats.The joint fibroblast-like synoviocytes(FLS) from AA rats were collected and incubated.Synoviocyte proliferation was determined by 3-(4,5-dimethylthiazal-2yl) 2,5-diphenyltetrazolium bromide(MTT) assay.Levels of PGE2 and cAMP were determined by radioimmunoassay(RIA).Results Level of PGE2 produced by FLS under the stimulation of rIL-1α(1,2,4,8,24 h)was elevated.Level of cAMP produced by FLS under the stimulation of rIL-1α (1,2,4,8 h)was elevated,but reduced in 24 h.GCS(100,50,25,12.5 mg·L-1) inhibited the proliferation and decreased the level of PGE2 and increased the level of cAMP.Conclusion GCS shows a capacity to reverse the rIL-1α stimulation on the FLS.
【Fund】: 国家自然科学基金资助项目(No30572356);; 安徽省科技攻关计划项目(No06013133B);; 安徽省教育厅自然科学基金资助项目(No2006KJ334B)
【CateGory Index】: R593.2;R285.5
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