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《Chinese Pharmacological Bulletin》 2009-05
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Effects of astragalosides on the expression of BDNF,TrkB and p75NTR mRNA against focal cerebral ischemia-reperfusion injury

YIN Yan-yan,LI Wei-ping,LI Wei-zu,GONG Hui-ling,ZHU Fen-fang,WU Guo-cui (Dept of Pharmacology,Anhui Medical University,Hefei 230032,China)  
Aim To observe the neurological protective effects of astragalosides(AST) on focal cerebral ischemia-reperfusion(I/R) injury in rats and to explore its possible mechanism.Methods Male SD rats received right middle cerebral artery occlusion for 120 min,and were decapitated 1,3,7,and 14 days after reperfusion.AST(40 mg·kg-1) was orally administered after I/R.Neurological deficit score was daily determined,the expressions of BDNF and p75NTR mRNA were detected by RT-PCR,and the expression of TrkB mRNA was detected by real-time PCR.Results AST reduced the neurological deficit score on days 3,increased the expression of BDNF mRNA on days 3,7 and 14,decreased p75NTR mRNA and increased TrkB mRNA on days 3 and 7.Conclusions AST improves the neurological deficits after I/R in rats.The mechanism may be related with increasing BDNF,and TrkB mRNA,and decreasing p75NTR mRNA.
【Fund】: 安徽省自然科学基金资助项目(No00144414);; 安徽省教育厅自然科学基金资助项目(NoKJ2008B301);; 安徽省高校自然科学研究项目(NoKJ2009A81);; 安徽省高等学校青年教师科研资助项目(No2008jq1059zd)
【CateGory Index】: R285.5
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