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Experimental study of theacrine on antidepressant effects

XIE Guo1,2,WU Min-zhi2,3,HUANG Ying-ru2,CAO Ya-ting2,LI Lai-dong2,ZHOU He-liang1,ZHU Rui2,LIAO Yan-feng2,KURIHARA Hiroshi1(1.Institute of Traditional Chinese Medicine and Natural Products,Jinan University,Guangzhou 510632,China;2.Institutes of Zhongshan,University of Electronic Science and Technology of China,Zhongshan Guangdong 528402,China;3.School of Pharmaceutical Sciences,Southern Medical University,Guangzhou 510515,China)  
Aim To investigate the antidepressant effects of theacrine (TC).Methods The antidepressant effects of TC were examined by a series of experiments including tail suspension test,forced swimming test,ambulatory activity test,yohimbine induced toxicity test,reserpine test and 5-HTP induced head-twitching test(The doses of groups were 3,10,30 mg·kg-1,bid respectively for continued 7 days of intragastric administration).Results Compared with the control group,TC could effectively shorten the immobility time in the tail suspension test (P0.05)and enhance the rotatory locomotor activities during forced swimming test (P0.05),but didn't affect the ambulatory activity.Moreover,TC also enhanced the mortality induced by yohimbine,and increased the head-twitching number induced by 5-HTP (P0.01).In addition,TC could markedly improve such symptoms as hypothermia (P0.01),akinesia (P0.05),and eye ptosis of mice (P0.01) induced by reserpine.Conclusions TC has antidepressant effects in various depression models of mice,which may be contributed to its influence on monoamine neurotransmitter.
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