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《Chinese Pharmacological Bulletin》 2009-09
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Effect and mechanism of astragalus polysaccharides on apoptosis of the islet beta cell in diabetes mellitus rats

MAO Shu-mei,LI Cheng-de,WANG Lin,WANG Jin-hong,DAI Gong,KANG Bai(Dept of Pharmacology,Weifang Medical College,Weifang Shandong 261042,China)  
Aim To probe the mechanism of the therapeutic effect of APS against DM rats by measuring the level of TNF-α,as well as observing the change of caspase-3 protein in pancreatic beta cells.Methods Thirty DM rats induced by STZ were randomly divided into three groups:DM group,APS low dosage group,APS high dosage group,and another 10 normal rats were taken as the control group.The drug was given for 6 weeks.The research included measuring the level of TNF-α in serum and the expression of caspase-3 protein in pancreatic beta cells.Results ① The level of TNF-α was higher in model group than that of the normal group(P0.05). APS could decrease the level of TNF-α(P0.05);② The expression of caspase-3 protein of beta cells in islet was significantly increased in DM rats,which was significantly inhibited by APS treatment.Conclusions APS can decrease the level of TNF-α and inhibit the apoptosis of beta cells in islet,which may be one of the mechanisms of APS improving DM.
【Fund】: 山东省教育厅资助课题(NoJ07WZ28);; 潍坊市科委资助课题(No200803066)
【CateGory Index】: R285.5
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