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《Chinese Pharmacological Bulletin》 2010-01
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Effects of curcumin on inflammatory reaction and blood-brain barrier permeability in rats following cerebral ischemic injury

LEI Jun-rong,QIN Jun,ZHANG Jing,HUANG Kuan-ming,FU Rui,ZHOU Zhang-ming (Taihe Hospital,Yunyang Medical College,Shiyan Hubei 442000,China)  
Aim To explore the effects of curcumin on inflammatory reaction and blood-brain barrier permeability in rats following cerebral ischemic injury,and to further investigate its potential mechanisms. Methods SD rats underwent the cerebral ischemia/reperfusion injury by the sutrure occlusion model were randomly divided into sham-control,cerebral ischemia and curcumin-treatment groups. Neurological deficit scores,cerebral infarction volume,brain water content and blood-brain barrier (BBB) permeability were measured,my-eloperoxidase(MPO) activities in rat brain were measured as an index of neutrophil infiltration; content of tumor necrosis factor-α(TNF-α)in rat brain was detected by ELISA;expression of matrix metalloproteinase-9 (MMP-9) in rat brain was determined by Western blot. Results Neurological deficit and cerebral infarction volume was decreased in curcumin-treatment group. The degree of neutrophilicgranulo cyte infiltration in cerebral tissues was decreased and the integrity of BBB was improved. Curcumin could also inhibit TNF-α and MMP-9 expression. Conclusion Curcumin exerts the neuroprotective effect on cerebral ischemia/reperfusion injury in rats through inhibiting the inflammatory reaction and improving BBB integrity,which may be associated with the inhibiton of TNF-α and MMP-9.
【CateGory Index】: R285.5
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