Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Pharmacological Bulletin》 2010-06
Add to Favorite Get Latest Update

High brain iron in etiology of Alzheimer's disease and therapeutic approaches

SUN Yi-min1,KONG Wei-na1,LI Guang-zhi2,CHAI Xi-qing1(1.Hebei Chemical & Pharmaceutical Vocational Technology College,Shijiazhuang 050026,China;2.The First People' s Hospital of Zhangjiakou,Zhangjiakou Hebei 075000,China)  
Excessive iron accumulation in the brain occurs in Alzheimer' s disease (AD) with oxidative stress,amyloid deposition,tau phosphorylation,and neuronal cell cycle regulatory failure,leading to apoptosis.Therefore,there is a direct link between iron metabolism and AD pathogenesis. The present review elaborates on high brain iron in etiology of AD and the development of iron-chelating therapy for AD,aiming at preventing or slowing down disease evolution.
【Fund】: 河北省教育厅科研计划资金资助项目(No2007433);; 河北省自然科学基金资助项目(NoC2010001471)
【CateGory Index】: R749.16
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 5 Hits
1 LIU Ling-yun1, CHAI Xi-qing2, LI Qing-jun1, CHENG Gui-hua2 (1Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, 2Faculty of Pharmacy, Hebei Chemical & Pharmaceutical Vocational Technology College, Shijiazhuang 050017, China);Effect of human hypoxia inducible factor-1α gene transfection on apoptosis of Aβ25-35 induced hippocampal neurons of primary culture[J];Acta Academiae Medicinae Militaris Tertiae;2007-07
2 WANG Ying-jie1,CHAI Xi-qing1,2,HAN Mei1,WEN Jin-kun1(1.Key Laboratory by Province and Education Ministry, Institute of Basic Medicine, Hebei Medical University,Shijiazhuang 050017,China;2.Hebei Chemical Pharmaceutical College,Shijiazhuang 050026,China);Inhibition of l-O-acetylbritannilactone on expression of COX-2 and NF-κB in rats hippocampus with AD[J];Chinese Pharmacological Bulletin;2008-04
3 ZHAO Lin,WEI Min-jie,HE Miao,JIN Wan-bao,ZHAO Hai-shan,YAO Wei-fan(Dept of Pharmacology,Pharmaceutical College of China Medical University,Shenyang 110001,China);The effects of tetramethylpyrazine on learning and memory abilities of mice with Alzheimer disease and its possible mechanism[J];Chinese Pharmacological Bulletin;2008-08
4 KONG Wei-na,AN Sheng-jun,CHAI Xi-qing(Hebei Chemical & Pharmaceutical College,Shijiazhuang 050026,China);The RAGE-Aβ interaction and its effects on pathogenesis of Alzheimers disease[J];Chinese Pharmacological Bulletin;2009-04
5 ZHU Ai-qin1,CHU Yi-de1,LI Qiao-xin2,Colin L Masters2(1.Institude of Geriatrics,Qinghai Province People's Hospital,Xining 810007,China;2.The University of Melbourne,The Mental Health Research Institute of Victoria,Parkville,3010 Australia);Tibet-medicine effects on β-amyloid pathology in a transgenic mouse model of Alzheimer's disease[J];Chinese Pharmacological Bulletin;2009-06
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 ZHOU Wei1,JIANG Zheng1,ZHANG Bin2,XIANG Ting-xiu1,HUANG Ai-long3,WANG Pi-long1(1Department of Gastroenterology,First Affiliated Hospital,2Department of Community Medicine,College of Public Health,3Institute of Viral Hepatitis,Chongqing Medical University,Chongqing 400016,China);RNA interference targeting hypoxia inducible factor-1α in BGC-823 cells inhibits cell proliferation and induces cell apoptosis[J];Acta Academiae Medicinae Militaris Tertiae;2009-02
2 YANG Xue-mei(The Central Hospital of Enshi Prefecture,Hubei Province,Enshi 445000,China);Research progress on the pharmacological effects of Ligustrazine[J];Chinese Journal of Biochemical Pharmaceutics;2010-03
3 SHAO Jian-lin,ZHOU Yin-yan,CHEN Hua-mei,WANG Yan,ZHAO GOU-liang,L Qiang,HENG Xin-hua,LUO Yong-yu(Dept of Anesthesiology,the First Affiliated Hospital,Kunming Medical College,Kunming 650031,China);Sevoflurane induces neuron HO-1 mRNA expression via P~(70S6K)/Nrf2 kinase signal pathways[J];Chinese Pharmacological Bulletin;2009-02
4 KONG Wei-na,AN Sheng-jun,CHAI Xi-qing(Hebei Chemical & Pharmaceutical College,Shijiazhuang 050026,China);The RAGE-Aβ interaction and its effects on pathogenesis of Alzheimers disease[J];Chinese Pharmacological Bulletin;2009-04
5 YAN Shi-jun,LI Zhi,ZHANG Wen-sheng (Protection and Utilization of Chinese Medicine Resources of Beijing Key Laboratory,Beijing Normal University;Center for Natural Medicine Engineering,The Ministry of Education of China,Beijing 100875,China);Glyoxalase I-structure,function and role in Alzheimer′s disease[J];Chinese Pharmacological Bulletin;2009-11
6 LI Wen-ming1,LIU Hong-tao2,LI Xiu-ying1,XU Gang1,YU Chao1 (1.Institute of Life Science,Chongqing Medical University, Chongqing 400016,China; 2.Dalian Institue of Chemical Physics,Chinese Academy of Science,Dalian Liaoning 116023,China);Effect of tetramethylpyrazine on lipopolysaccharide-induced damage in vascular endothelial cell[J];Chinese Pharmacological Bulletin;2009-11
7 QIAO Lin-xia,TANG Qing-ya Clinical Nutrition Center,Xinhua Hospital,Medical College,Shanghai Jiaotong University,Shanghai 200092, China;Compatibility and efficiency of iron in parenterai nutrition admixtures[J];Chinese Journal of Clinical Nutrition;2009-04
8 WANG Shi-long,LIN Yuan,TANG Ze-Yao(Dept of Pharmacology,Dalian Medical University, Dalian Liaoning 116044,China);Research progress on the protection of tetramethylpyrazine in different kinds of damage of nervous system and its mechanisms[J];Chinese Pharmacological Bulletin;2010-04
9 YUAN Shu-min,CAO Xing-shui,GAO Xiang,ZHANG Hai-tao,ZHANG Lian-feng,QIN Chuan(Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences &Peking Union Medical College,Key Laboratory of Human Disease Comparative Medicine,Beijing 100021,China);Influence of Tetramethylpyrazine on Learning and Memory in APPswe /PSΔE9 Double-transgenic AD Mouse Model[J];Chinese Journal of Comparative Medicine;2010-05
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Li Xi( Second Affliated Hospital of Xi' an medical University, Xi' an );Effect of Nao Er Kang on Learning and Memory Disorders in Model Rats with Alzheimer's Diseases[J];China Journal of Traditional Chinese Medicine and Pharmacy;2001-05
2 LIU Ling-yun1, CHAI Xi-qing2, LI Qing-jun1, CHENG Gui-hua2 (1Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, 2Faculty of Pharmacy, Hebei Chemical & Pharmaceutical Vocational Technology College, Shijiazhuang 050017, China);Effect of human hypoxia inducible factor-1α gene transfection on apoptosis of Aβ25-35 induced hippocampal neurons of primary culture[J];Acta Academiae Medicinae Militaris Tertiae;2007-07
3 DUAN Dongxiao 1), ZHANG Guihong 1),XING Yin 1), GAO Xiaoqun 2), RU Liqiang 2) 1)Department of Physiology, Medical College, Zhenzhou Universty,ZhengZhou 450052 2)Department of Neurobiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030;Effect of hypoxic pretreatment on expression of hypoxic-inducible factor-1α in transient focal cerebral ischemia rats[J];Journal of Zhengzhou University(Science Medical);2004-06
4 SHEN Yu Xian, YANG Jun,WEI Wei,LIU Li Hua,XU Shu Yun (Institute of Clinical Pharmacology,Anhui Medical University,Hefei 230032);Induction of learning and memory dysfunction by β-amyloid peptide fragment 25~35 in rats[J];Chinese Pharmacological Bulletin;2001-01
5 XU Hong-bin,JI Hui,LIU Guo-qing (Dept of Pharmacology,China Pharmaceutical University,Nanjing 210009,China);Immunotherapy for Alzheimers disease[J];Chinese Pharmacological Bulletin;2006-04
6 LI Yuan-hai~ 1,2 , LI Jun~1, L Xiong-wen~1, JIN Yong~1, HUANG Yan~1, ZHANG Lei~1 (1.School of Pharmacy, Anhui Medical University, Hefei 230032,China;2.Dept of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022,China);Effects of interaction between propofol and ligustrazin on hepatic ischemia-reperfusion injury in rat[J];Chinese Pharmacological Bulletin;2006-04
7 JIN Ying~1,YAN En-zhi~1,FAN Ying~1,QI Zhi-min~1,Bao Cui-fen~2(1.Dept of Pharmacology,2.Centre of Scientific Experiments,Jinzhou Medical College,Jinzhou 121001,China);Effects of sodium ferulate on Aβ_(25-35)-induced cognitive deficits and expression of IL-1β and p38MAPK in rats[J];Chinese Pharmacological Bulletin;2006-05
8 SHU Bing, ZHOU Chong-jian, MA Ying-hui, WANG Yong-jun, SHI Qi (Spinal column Institute of Shanghai University of Traditional Chinese Medicine, Shanghai 200032);Research progress on pharmacological activities of the available compositions in Chinese medicinal herb Ligusticum chuanxiong[J];Chinese Pharmacological Bulletin;2006-09
9 CHEN Gang~1,XU Xiao-yu~2,YE Lan~3,CHEN Wei-hai~3,HU Yi-yong~3,FENG Jun-dong~3(1.Research Center of Pharmaceutical,Chongqing Technology and Business University,Chongqing 400067,China;2.College of Traditional Chinese Medicine and Pharmacy,Southwest University,Chongqing 400715,China;3.Dept of Pharmacy,Chongqing Medical University,Chongqing 400016,China);Effects of tetramethylpyrazine on the expression of vascular endothelial growth factor in synovium of collagen-induced arthritis in rats[J];Chinese Pharmacological Bulletin;2006-10
10 GAO Yun,LIANG Shang-dong(Dept of Physiology,Medical College of Nanchang University,Nanchang 330006,China);Animal model of neuropathic pain and its application to research on pain mediated by P2X receptors[J];Chinese Pharmacological Bulletin;2006-11
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved