Full-Text Search:
Home|About CNKI|User Service|中文
Add to Favorite Get Latest Update

Effects of TFE from two species of Epimedium in Guizhou on the learning and memory abilities in dementia model rats

DENG Wei,ZHENG Min-qiang,ZHANG Jing,HUANG Cong(Dept of Pharmacology,Guiyang College of Traditional Chinese Medicine,Guiyang 550002,China)  
Aim To study the effects of TFE from Epimedium acuminatum and E.leptorrhizum grown in Guizhou on the learning and memory abilities of dementia model rats induced by D-gal-AlCl3 compound method.Methods The dementia model rat was induced by the D-gal-AlCl3 while 4 groups given TFE of 100,50 mg·kg-1.The Morris Water Maze was used to test their spatial learning abilities.Detect the activity of AChE in serum and brain with the biochemical method.The immunohistochemical technique was used to determine the level of Bcl-2/Bax.Results The learning and memory abilities deficit rat model was induced by the D-gal-AlCl3.The TFE improved the learning and memory abilities of the dementia rats,decreased the activity of AChE in brain and blood tissue,obviously increased the level of Bcl-2,and lowered the level of Bax.The TFE from Epimedium acuminatum was better in improving the memory abilities.Conclusions The Epimedium acuminatum is superior in enhancing the memory of dementia rats and reducing brain cell apoptosis.The results imply that ICA in TFE is the main substance for memory improvment.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©CNKI All Rights Reserved