Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Pharmacological Bulletin》 2011-07
Add to Favorite Get Latest Update

Ulinastatin protects the lung against ischemia-reperfusion injury with CPB by upregulating the expression of pulmonary aquaporin 1 in neonatal pig

RONG Jian1,YE Sheng2,XIAO Liang-can1,GUO Jun-ying1,LIANG Meng-ya3,LIU Hai3,HUANG Wei-ming1,WU Zhong-kai3 (1.Dept of Anesthesiology,2.Dept of Oncology,3.Dept of Cardiac Surgery,the First Affiliated Hospital,SUN Yat-sen University,Guangzhou 510000,China)  
Aim To observe the lung protection and expression of pulmonary aquaporin 1(AQP1) by ulinastatin following ischemia-reperfusion during CPB in neonat pig.Methods Twelve neonatal pigs were randomized into two groups: control group(n=6) reveived normal cardiopulmonary bypass;test group(n=6) received ulinastatin by pulmonary artery.Lung injuries,which was marked by pulmonary pathology,PMN in BALF,IL-6 and TNF-α in pulmonary vein and pulmonary wet/dry weight(W/D) were analyzed.Expression of aquaporin 1 were analyzed by immunohistochemistry and Western blot.Results Compared with control group,pathological scores,PMN in BALF,IL-6,TNF-α and W/D in test group at T2 were significantly lower(P0.05).Expression of AQP1 in test group increased significantly at T2(P0.05).Conclusions Ulinastatin is protective on the lung ischemia-reperfusion injury with CPB in neonatal pig.The protective effects were related with its upregulation of aquaporin 1.
【Fund】: 广东省科技计划资助项目(No2010B031600217)
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved