Role of acid-sensing ion channel 1a in pathogenesis of autoimmune diseases
CHEN Yong;GE Jin-fang;CHEN Fei-hu;School of Pharmacy,Anhui Medical University;
Acid-sensing ion channels( ASICs) are proton-gated channels expressed widely in the central nervous systems and peripheral tissues,among which ASIC1 a is a core part and plays an important role in many physiological and pathological processes. As a key receptor for extracellular protons,ASIC1 a is involved in a variety of pathophysiological processes involving tissue acidosis,such as pain,inflammation,seizures and multiple sclerosis. Autoimmune disease is a chronic inflammatory disease,and the excessive activation of T,B cells leads to multiple tissue and organ damage when the body responds to autoantigen immune response. In recent years, studies have found that ASIC1 a plays an important role in the development of various autoimmune diseases. In this paper,the biological characteristics of ASIC1 a are briefly reviewed,and the research progress of ASIC1 a in the development and progression of autoimmune diseases is discussed.