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The effects of the three components isolated from astragalus mongholicus bunge on scavenging free radical

WANG De-Qing;SHEN Wen-Mei;TIAN Ya-Ping et al(Dept.of Biochemistry, General hospital of PLA,Beijing 100853)  
The effects of Total Flavonoids of Astragnlus(TFA), Total Saponins of Astragalus(TSA) and Total Polysaccharide of Astragalus(TPA) isolated from Astragalus mongholicus Bunge on luminol chemiluminescence (CL) emitted by Xanthine/Xanthine Oxidase(Xan/XO) and PMA stimulated polymorphnuclear leukocytes(PMN), and lipid-peroxidation of rat liver homogenate induced by H2O2-Fe2+ were studied The results showed that both TFA and TSA possessed the ability for depressing CL and in hibiting the lipid peroxidation. Comparing their effects.the effect of TFA was stronger than that of TSA.Whereas,TPA had a little inhibiting effect on Xan/XO emitted CL, enhancing the respiratory burst of PMA stimulated PMN and lipid peroxidation of rat liver homogenate,and no effect on generating respiratory burst of PMN. It is indicated that TFA and TSA are main active constituents for anti-free radical in Astragalus monghlicus Bunge.
【CateGory Index】: R282.710.5
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