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《CHINESE PHARMACOLOGICAL BULLETIN》 1994-02
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Protective effect of gypenosides on OFR-induced damage of relaxing capacity of rabbit thoracic aortae in vitro

XIAO Guan-Lian,LIAO Duan-Fang; CHEN Jian-Xiong; YU Lin (Dept.of pharmacology, Hengyang Medical College, Hunan 421001)  
In isolated rabbit thoracic aortae,we investigated the protective effect of gypenosides(GPs) on aortic damage induced by exogenous oxygen free radicals(OFR).The data showed that both electrolysed Krebs solution and xanthine-xanthine oxidase decreased the relaxation of the aortic rings induced by ACh.GPs(50mg·L-1) significantly protected the relaxing capacity of the aortic rings from OFR,so did catalase(25 mg· L-1).The protective effect was abolished by cyclooxgyenase inhibitor indomethacin(5 μmol· L-1).GPs also resisted the decrease of relaxation of the rings induced by methylene blue.
【CateGory Index】: R282.710.5
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