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Antimutagenic effects of Gypenosides(GP)in salmonella test

WANG Ying-Jin;BAI Yuan-Rang (Dept of Pharmacology, Xi'an Medical University, Xi'an 710061)  
Aset of histidine-requiring strains TA97.TA98.TA100,TA102was used for antimutagenicity test.4 mutagenic agents such as Atabrine(AB).Daunorubicin (DN).Sodium Axide(SA).Mitomycin C(MMC) were used to make mutagenic model and antimutagenic effects of GP was observed,Every tester strain was divided intocontrol group·model group and GPgroups.AB.DN.SA and MMC were mutagenic agents for TA97,TA98,TA100and TA102respectively.The results showed that GPinhibited mutagenic effects induced by 4 model agents. The inhibitory rates were56.0% ,74.7% .94.5% for AB; 23.1% , 40.2% , 57.9% for DN; 34.0% , 59.3%, 94.5% for SA and 22.0% . 50. 5% . 64. 3% for MMC respectivelThese data suggestthat GP has the effects of inhibiting mutagenesis induced by AB.DN, SA, MMC insalmonella test with dose-dependent manner and is very likely to have a protective action on the carcinogens.
【CateGory Index】: R96
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