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《CHINESE PHARMACOLOGICAL BULLETIN》 1996-04
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Vasodilating mechanism of epimedium icariine

GUAN Li-Xin;YI Xin;YANG Li-Yan;LU Yi-Fang(DePt of Pharmacology,Mudanjiang medical College,Mudanjiang 157011)(Dept of Pharmacology,Norman Bethune University of Medical Sciences,Changchun 130021)  
The epimedium icariine(EI) was isolated from the stem and leaves of epimedium brevicornum Maxim,and the vasodilating mechanism of EI was studied on the isolated aortic strips of rabbits.EI(20,40 mg·L-1) could non-competitively antagonize the dose-response curves of norepinephrine(NE),potassium chloride and calcium chloride.At the concentration of 30 mg·L-1,EI significantly inhibited the extracellular Ca2+-dependent contraction of aortic strips induced by NE,however,it didn't inhibit the intracellular Ca2+-dependent contraction of aortic strips induced by NE.EI(30 mg·L-1) pro duced neither α-adrenoceptic stimulating nor β-a drenoceptic blocking effects.These results indicated that the vasodilating mechanism of EI might have associated with its blocking calcium channels.
【Key Words】： epimedium icariine thoratie aorta potassium chloride norepinephrine
【CateGory Index】： R285.5
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