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Effects of berberine sulphate on immune system

GENG Dong Sheng, LIU Fa, LIU Xue Bin, YANG Yong Xin (Department of Pharmacology, Xinjiang Medical College, Urumqi 830054)  
In previous studies, it found that berberine had the effects of antibacteria, anti inflamation and restraining the growth of tumor cells. These should have been closely connected with immunity effects. Therefore, we had studied the effects of berberine sulphate (BS) on immune system of mice in vitro and vivo . The results showed that BS with 10 -4 and 10 -5 mol. L -1 increased phagocytosing function of peritoneal macrophages (PMΦ) in mice and peripheral leukocytes in human, the production of IL 1 by PMΦ in mice, inhibited the production of IL 2 produced by spleen cells, the lymphocyte transformatiom of both T and B. With 25,50 mg·kg -1 , BS accelerated the clearance rate of charcoal particles, decreased the development of serum hemolysin concentration 50% and the delayed type hypersensitivity reaction. It was suggested that BS increase non specific and decrease specific immunity in mice.
【CateGory Index】: R967
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