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《CHINESE PHARMACOLOGICAL BULLETIN》 1997-03
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Regulatory mechanism of total glucosides of paeony on tumor necrosis factor production by peritoneal macrophages in rats

WANG Bin, CHEN Min Zhu, XU Shu Yun (Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032)  
AIM: To determine different concentrations of total glucosides of paeony(TGP) regulating tumor necrosis factor(TNF) production by peritoneal macophages(MΦ) in rats. METHODS: 45 Ca influx, the amount of prostaglandin E 2(PGE 2) and TNF in MΦ media were measured in the presence or absence of the inhibitors of cycloxygenase and calmodulin and other tool drugs. RESULTS: TGP(0 5 ̄10 mg·L -1 ) markedly increased both 45 Ca influx and TNF production in MΦ induced by lipopolysaccharide(LPS,5 mg·L -1 ). Linear regression analysis demonstrated a positive correlation between 45 Ca influx and TNF production. Trifluoperazine(40 μmol·L -1 ) could block the enhancing TNF production in TGP LPS activated MΦ cultures. The concentration effect curve of TGP LPS for TNF release seemed to be bell shaped, but that for PGE 2 secretion was enhanced in a concentration related way. There was a significant positive correlation between TNF and PGE 2 production when TGP in lower concentrations(0 5 ̄12 5 mg·L -1 ), but a negative correlation when TGP in higher ones(12 5 ̄250 mg·L -1 ). The descending limb of the curve of TNF was disappeared when indomethacin(10 μmol·L -1 ) was added, while its curve did not change when added Nω nitro L arginine(15 μmol·L -1 ). CONCLUSIONS: Up regulation of lower concentrations of TGP on TNF production may be associated with increasing 45 Ca influx and activating the calmodulin activity and then enhancing PGE 2 production, and down regulation of higher concentrations may be mediated through the excess PGE 2 production by MΦ itself.
【CateGory Index】: R977.1
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【References】
Chinese Journal Full-text Database 10 Hits
1 Li Xiaomei,Li Xiangpei,Wang Guosheng,et alDepartment of Rheumatology,Anhui Provincial Hospital,Hefei 230001;Effectiveness and safety of total glucosides of peony in the treatment of patients with Sjogren syndrome[J];;2006-05
2 SHI Peng Department of Nephrology, PLA 451 Hospital, Xi'an 710054, China;Effects of total glucosides of paeony on active Heymann nephritis in rats[J];Journal of The Fourth Military Medical University;2005-18
3 SHU Qiang~* LI Xing-fu LI Dong HOU Huai-shui DAI Guo-feng LIU Hua-xiang. ~*Department of Rheumatology,Qilu Hospital of Shandong University,ji'nan 250012,China;Effect of total glucosides of paeony on the proliferation of fibroblast-like synovial cells in osteoarthritis[J];Chinese Journal of Rheumatology;2007-08
4 XIAO Kun~* (Department of Clinical Medicine,Peking Union Medical College,Beijing 100730,China);Application of Total Glucosides of Peony in Autoimmune Diseases[J];Chinese Journal of Allergy and Clinical Immunology;2008-01
5 WANG Wenjun, WANG Peixun, LIANG Ruiyan(Institute of Immunology, Guangzhou University of TCM, Guangzhou 510405, China);Studies on In-Vitro Biological Activity of Albiflorin R1 in Counteracting Cell Proliferation[J];Journal of Guangzhou University of Traditional Chinese Medicine;2005-01
6 TONG Juan1,CHEN Guangxing2,LIU Qingping2,ZHAO Shizhe2,CHEN Jifan2 (1.Dept.of Acupuncture & Moxibustion,the First Affiliated Hospital,Guangzhou Medical College,Guangzhou 510120,China;2.Dept.of Internal Medicine,the First Affiliated Hospital,Guangzhou University of TCM,Guangzhou 510405,China );Effect of Tongbiling on Articular Damage in Collagen-induced Arthritis Rats[J];Journal of Guangzhou University of Traditional Chinese Medicine;2007-04
7 XU Hong,DOU Xue-rong,WANG Bo-song(1.Dept.of Cardiology,Taian Central Hospital Taian,Taian 271000,China;2.Dept.of Cardiology,Taishan Sanatorium of Shandong,Taian 271000,China);The effects of total glucosides of paeony on proliferation of synoviocytes from rabbit adjuvant arthritis[J];Journal of Taishan Medical College;2007-02
8 JIN Gui-lan,WANG Yue(Nanjing University of Traditional Chinese Medicine,Nanjing 210046,China);Experimental Research of the Method of Nourishing Both "Qi" and Blood on the Mice Having SS[J];Lishizhen Medicine and Materia Medica Research;2009-12
9 JIANG Hong, HUI Qi-hua, CHEN Yong-zhen, et al (Suzhou Hospital of TCM, Suzhou 215003,China);Study of Tongfengping on Pathological Changes of Synovial Membrane in Rabbit Experimental Acute Goute Arthritis[J];Chinese Journal of Information on TCM;2005-03
10 ZHOU Qiang,LI Zhan guo (Department of Rheumatology and Immunology, People's Hospital, Peking University, Beijing 100044, China);Pharmaceutical effects of total glucosides of peony and its application in autoimmune disease[J];Chinese Journal of New Drugs and Clinical Remedies;2003-11
【Citations】
Chinese Journal Full-text Database 3 Hits
1 WANG Bin; CHEN Min-Zhu; XU Shu-Yun(Institute of Clinical Pharmacology,Anhui medical University,Hefei 230032);Effect of total glucosides of paeony (TGP) on tumor necrosis factor produced by peritoneal macrophages in rats[J];CHINESE PHARMACOLOGICAL BULLETIN;1995-01
2 LIJun;LIANGJun-Shan;.ZNOU Ai-Wu;CHEN Min-Zhu;XU Shu-Yun(Institute of Clinical Pharmacology,Anhui Medical University,Hefei 230032);Modulatory effects of total glucosides of paeony on B lymphocyte proliferation and interleukin 1 production[J];CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY;1994-01
3 Cheng Jinxuan, Duan Jinhong, Han Fengyun, Ge Lin, Wang Zhengang and Shi Yiqing(Institute of Basic Medical Sciences,Beijing);Radioimmunoassay for Prostaglandin E_2[J];Acta Academiae Medicinae Sinicae;1987-03
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Wang Yuwei,Wang Yongjun Zhejiang Chinese Medical University Hangzhou(310053);Pharmacological Study and Clinical Application of Total Glucosides of Peony in Autoimmune Diseases[J];Journal of Zhejiang University of Traditional Chinese Medicine;2007-02
2 Li Xiaohui,Tang Ruyu (Department of Pharmacology,Third Military Medical College,Chongqing,630038);Study of the injurious effects of neutrophils on myocardium and their medicinal therapy in rabbits[J];Acta Academiae Medicinae Militaris Tertiae;1993-05
3 SHEN You-xuan, LIU Xiao-hua. Department of Rheumatology, The first Affiliated Hospital of Nanjing Medical University, Jiangsu 210029, China;Study of effect of total peony glucosides on hypergammaglobulinemia in undifferentiated connective tissue disease[J];Chinese Journal of Rheumatology;2005-01
4 SHU Qiang~* LI Xing-fu LI Dong HOU Huai-shui DAI Guo-feng LIU Hua-xiang. ~*Department of Rheumatology,Qilu Hospital of Shandong University,ji'nan 250012,China;Effect of total glucosides of paeony on the proliferation of fibroblast-like synovial cells in osteoarthritis[J];Chinese Journal of Rheumatology;2007-08
5 WU Yu-mei, XU Han-peng, WANG Chun-ting, LI Jing-wen, JU Gong * (Neuroscience Research Institute of PLA, the Fourth Military Medical University, Xi'an 710032,China);THE EFFECT OF PAEONIFLORIN ON VIABILITY OF RAT CORTICALASTROCYTES in vitro[J];Acta Anatomica Sinica;2002-04
6 Ynag Chi; Qiu Weiliu;Ha Qi; et al. (Department of Oral andMaxillofacial Surgery, Affiliatted Ninth Hospital of Stomatology,Shaghai Second Medical University, Shanghai 200011) To gain fur ther knowledge about the maraca mulatoo’s applied anatomic characte;THE EXPERIMENTAL METHODOLOGY IN THE MARACA MULATTO′S ORAL AND MAXILLOFACIAL REGIONS[J];CHINESE JOURNAL OF ORAL & MAXILLOFACIAL SURGERY;1996-04
7 Chen Tielou,Stomatological Research Center of Navy(200081);Zhou Yijun,Wu Zhifen,Stomatological College of Fouth Militory Medical University(710032);TheRelationshipBetweenPGE2、6-K-PGF1aandTXB2inGingivawithPeriodontalDiseaseandPeriodontalDiseasesChenTielou,StomatologicalResearchCenterofNavy(200081);ZhouYijun,WuZhifen,StomatologicalColegeofFouthMilitoryMedicalUniversity(710032)AbstractAim:Tostudytherel[J];STOMATOLOGY;1998-04
8 LI Yan-ju1,LIU Hui2,GUO Yue-qiu3,MA Lian-xue4(1.Examining Department,Dalian Development Zone Hospital,Dalian 116600,Liaoning,China;2.Clinic Immunology Teaching and Research Center,Dalian Medical University,Dalian 116027,Liaoning,China;3.TCM office,Dalian Institution of Drug Control,Dalian 116021,Liaoning,China;4.Examining Department,Fushun Mineral Hospital,Fushun 113008,Liaoning,China);The Research of Immune Regulation Effects of Three Chinese Medicines Based on Chinese Medicine Informatics[J];Liaoning Journal of Traditional Chinese Medicine;2007-06
9 LUO Wen-feng,CHEN Jing,PENG Yuan-hong (Department of Rheumatology and Hematology,the Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000);Curative Effect of Total Glucosides of Peony Therapy on Elderly Patients with Chronic Idiopathic Thrombocytopenic Purpura[J];Journal of North Sichuan Medical College;2009-02
10 XIAO Kun~* (Department of Clinical Medicine,Peking Union Medical College,Beijing 100730,China);Application of Total Glucosides of Peony in Autoimmune Diseases[J];Chinese Journal of Allergy and Clinical Immunology;2008-01
China Proceedings of conference Full-text Database 1 Hits
1 LIANG Yuanyuan, ZHU Chenchen(New Drug Research& Development Center, Guangzhou University of TCM, Guangzhou, 510405);Determination of Paeoniflorin in Gujing Pill by HPLC[A];[C];2004
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 HU Cheng-mu,JIANG Hui,LIU Hong-feng,LI Rong,LI Jun (School of Pharmacy,Anhui Medical University,Hefei 230032);Effects of LJTF on immunological liver injury in mice[J];Anhui Medical and Pharmaceutical Journal;2008-04
2 CHEN Fang-jun1,2,WANG Jia-jia1,LI Jun1(1.Anhui Medical University,Hefei,230032;2.Anqing Medical College,Anqing,246003);Protective effect of polysaccharides from yu-ping-feng powder on immunological liver injury in mice[J];Anhui Medical and Pharmaceutical Journal;2008-04
3 SHAO Fu-rong,WEI Wei,LIU Hao,SUN Wu-yi,LI Xiang(Institute of Clinical Pharmacology of Anhui Medical University, Anhui Hefei 230032,China);Comparison of Protective Effect of Shaoqiduogan Extracted by Different Methods on Immunological Liver Injury in Mice[J];Journal of Anhui Traditional Chinese Medical College;2007-05
4 XIA Lun-zhu,XU Xian-xiang,ZHANG Rui(The First Hospital Affiliated to Anhui College of Traditional Chinese Medicine,Anhui Hefei 230031,China);Antiinflammatory Effects of Total Saponins of Radix Clematis in Rats with Carrageenan-induced Inflammation[J];Journal of Anhui Traditional Chinese Medical College;2009-03
5 DENG Yu-lin,DING Li-qun, YANG Bin (School of Life Science and Technology, Beijing Institute of Technology, Beijing100081, China);Anti-Inflammatory, Analgesia and Bacteriostatic Effects of Shuyixin[J];Journal of Beijing Institute of Technology;2004-08
6 YANG Mu-xiang1,YU Wen-tao1,XU Hua-zhou2,WANG Xiao-hong2,YANG Jie-wen3(1College of TCM,Hebei Medical University,Shijiazhuang 050091,China;2The Second Affiliated Hospital of Hebei Medical University,Shijiazhuang 050000,China;3Handan Hospital of TCM,Handan 056001,China);Effect of Kechuanning on expression of NF-кB in lung tissue of bronchial asthmatic rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2008-09
7 WANG Yin,LI Ji(The 455th Hospital of PLA,Shanghai 200052,China);The study of anti-inflammatory effects of faucitis preparation[J];Journal of Southeast China National Defence Medical Science;2006-03
8 SHI Peng Department of Nephrology, PLA 451 Hospital, Xi'an 710054, China;Effects of total glucosides of paeony on active Heymann nephritis in rats[J];Journal of The Fourth Military Medical University;2005-18
9 REN Feng-lian,QU Bai-lu and TAN Xiao-yan(College of Chemistry and Chemical Engineering,Central South University,Changsha 410083);Determination of total glucoside content of paeony in Paeonia lactifloria Pall.by Alkaline hydrolysis-UV spectrophotometry[J];Chinese Journal of Analysis Laboratory;2008-10
10 JIANG Xing-lin1,JIANG Le-long1,HU Xiang-shang1,WANG Yu-ai1,TIAN Xiao-ying1,DENG Wei-feng1,FANG Hua2,LIU Hui2(1.Department of Laboratory Medicine,Huaihua Medical College,Huaihua Hunan 418000;2.Dalian Medical Universty);Probe into the Influence to Mouse Body Fluid Immunologic Function by TCM Paeonia Lactifiora Pallas[J];Journal of Huaihua Medical College;2006-02
China Proceedings of conference Full-text Database 1 Hits
1 Hu Chengmu Jiang Hui Liu Hongfeng Li Rong Li Jun (School of Pharmacy,Anhui Medical University,Hefei 230032);Protective effect of Lonicera japonica total flavone(LJTF)on immunological liver injury in mice[A];[C];2007
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 Liang Junshan, Wei Wei & Zhou Aiwu (The Institute of Clinic Pharmacology, Anhui Mecical University, Hefei 230032);METHOD FOR MEASURING IL-1 AND EFFECTS OF TOTAL GLUCOSIDES OF PAEONY ( TGP ) ON IL-1 PRODUCTION[J];Chinese Pharmacological Bulletin;1989-06
2 Guan Yongyuan, Chen Keming, Sun Jiajun ( Dept. of Phar., Sun Yat Sen University of Medical Sciences, Guangzhou 510089) Kwan C Y, Daniel E E ( Dept. of Biomedical Sciences, McMaster University, Hamilton, Ontario , Canada );EFFECTS OF PANAX NOTOGINSENG SAPONlNS ON THE ~(43)CA-INFLUX AND EFFLUX INDUCED BY ACTIVATION OF α-1 ADRENOCEPTOR OF VASCULAR SMOOTH MUSCLE[J];Chinese Pharmacological Bulletin;1990-04
3 Zhou Dao-hong Shen Yuan-shan Zhao Man-rut (Department of Microbiology, Henan Medical University);The Application of MTT Colorimetric Assay to Measured the Proliferation of Lymphocytes and the Activity of Rat/Mouse IL2[J];Chinese Journal of Immunology;1986-01
4 Cheng Jinxuan, Shi Yiqing, Ge Lin, Duan Jinhong and Wang Zhengang(Institute of Basic Medical Sciences, Beijing);Preparation of Prostaglandin E(PGE) Antibodies and Its Technical Improvements[J];Acta Academiae Medicinae Sinicae;1986-02
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