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《CHINESE PHARMACOLOGICAL BULLETIN》 1998-01
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Effect of GP on action potentials,Lcalcium channel currents, sodium channel currents and potassium channel currents in isolated single ventricular myocyte of guinea pigs

ZHAO Ying, HU DaYi(Lab of Heart Center, Beijing Red Cross Chao Yang HospitalAffiliate of Capital University of Medicine, Beijing 100020)  
AIM To investigate the effects of GP on action potentials, Lcalcium channel currents, sodium channel currents and potassium channel currents in isolated single ventricular myocyte of guinea pig. METHODS Whole cell recording by patch clamp technique. RESULTS GP 50 mg·L-1 shortened action potential duration (APD90) 581% and shortened action potential amplitude (APA) 241%, but had no significant effects on rest membrane potential (RMP). GP 5 ̄50 mg·L-1 inhibitted calcium currents and sodium currents. The inhibition was concentrationdependent. GP did not effect inward rectified potassium currents. CONCLUSIONS GP might prevent cardial myocyte from ischemic damage by inhibitting the “calcium overload” and generation of abnormal excitement.
【CateGory Index】: R331.3,R284.1
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