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Therapeutic role and its mechanism of gypenosides on delayed healing of experimental gastric ulcer induced by NCTC11637 strain HP in rats

ZHANG Qing Bei 1,MA Jun Jiang,CHAO Zhi Xian 2,LIN Zhi Bin (Dept of Pharmacology, Beijing Medical University, Beijing 100083)  
AIM To investigate the adverse action of Helicobacter pylori (HP) (NCTC11637 strain) and the therapeutic effect of Gypenosides (GP) on ulcer healing in rats. METHODS After ulcer induction by acetic acid in the stomach, rats were divided into 4 groups. They were either given ig with distilled water or with CagA (+) and VacA(+) NCTC11637 HP (1 mg·kg -1 ·d -1 ) alone or together with GP (15 or 45 mg·kg -1 ·d -1 ) for 9 days. The changes of ulcer size, IL 8, PGE 2, MDA, SOD and ·OH in the gastric mucosa were assessed. RESULTS Administration of HP significantly increased the ulcer sizes and mucosal levels of IL 8, PGE 2 and MDA. The SOD activity reduced. These changes were alleviated by GP treatment. CONCLUSION NCTC11637 strain of HP could delay ulcer healing. GP administration reversed this adverse action by inhibiting the inflammatory responses, including IL 8, lipid peroxidation and hydroxyl free radical formation in the gastric mucosa. It also increased the protective effects through the stimulating action on SOD activity in the stomach.
【Fund】: 高等学校博士学科点专项科研基金
【CateGory Index】: R284.1
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