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《CHINESE PHARMACOLOGICAL BULLETIN》 1999-03
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A model of adriamycin induced nephropathy after pinealectomy

XIONG Zu Ying, MEI Qiao, DING Chang Hai, XU Shu Yun (Dept of Nephrology, The First Hospital of Anhui Medical University Insititute of Clinical Pharmacology, Anhui Medical University, Hefei 230032)  
AIM To produce a special animal model of adriamycin induced nephropathy after pinealectomy in Wistar rats. METHODS Before the rats were injected adriamycin (5 mg·kg -1 ) vialtail vein, their pineal glands were removed by surgical operation. At 0,1,2 and 4 week, urinary excretion protein (UAE) and plasma parameter in all rats were investigated. RESULTS The typical nephrotic syndrome was found in group adriamycin administration(ADR) and in group pinealectomy with adriamycin administration (PX+ADR). UAE level in group PX+ADR increased more significantly ( P 0 01) than that in group ADR (1024 97±137 02, 407 07±68 66 mg·d -1 , respectively). The similar change was found in plasma cholesterol of group ADR and PX+ADR. Plasma total protein and albumin levels in group ADR decreased more markedly ( P 0 01) than that in group PX+ADR. The main dead cause of rats was operation complications with pinealectomy. CONCLUSION This special animal model is a great tool to study relationship between pineal gland and chronic nephropathy
【CateGory Index】: R-332
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