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《Journal of Genetics and Genomics》 2007-11
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Identification of Differentially Expressed MicroRNAs During the Development of Chinese Murine Mammary Gland

Chunmei Wang,Qingzhang Li Key laboratory Dairy Science of Education Ministry Northeast Agricultural University,Harbin 15000,China  
MicroRNAs (miRNAs) are endogenous ~22 nucleotide-long noncoding RNAs. In this study,to investigate miRNA ex-pression profiles and their functions in mammary gland development,we have used microarray as well as qRT-PCR,to analyze the miRNA expression changes along the murine mammary cycle during pregnancy,particularly on transition from pregnancy to lacta-tion. It shows that every developmental stage of the mammary gland has its own miRNA expression pattern. Compared with virgin and involution,some miRNAs such as miR-138 and miR-431 are downregulated,whereas,some miRNAs such as miR-133 and miR-133a-133b are upregulated during pregnancy and lactation. These results indicate that miRNAs are functionally involved in mammary gland development.
【Fund】: This work was supported by the Doctor Study Project of Heilongjiang Education in 2005.
【CateGory Index】: Q3
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1 WANG Fen,LI Zhao-hui (Department of Forensic Medicine,Zhongshan school of Medicine,Sun Yat-sen University,Guangzhou 510080,China);A Study on miRNA Alternation after H_2O_2-induced PC12 Cell Apoptosis Using Microarray Technique[J];Journal of Forensic Medicine;2007-05
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