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《Hereditas(Beijing)》 1996-06
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Mitochondria DNA Sequence Analysis of 3 Cases with Aminoglycoside Antibiotics Induced Deafness

Zhang Lishan; Zhang Zhiping; Zhou Xiaolei; Huang Ying ;Xi Rongnan(Department of Biology, Nanjing Railway Medical Collge, Nanjing 210009)  
The mitochondria DNAs (mtDNAs) of thrce patients with AAID were analysed using the method of direct sequeneing of their PCR produets. The results showed that all their mtDNAs had an A-G mutation at nucleotides 1 555. It is considered that this mutation is the molecular basis causing human susceptibility to Aminoglycoside Antibiotics toxicity which in coopcration with Aminoglycoside Antibiotics results in deafness.
【Fund】: 国家自然科学基金
【CateGory Index】: Q343
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