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《Hereditas(Beijing)》 2001-02
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Methods of QTL Interval Test Based on Trait-Marker Regression

WU Wei-ren,LI Wei-ming (College of Crop Science, Fujian Agricultural University, Fuzhou 350002, China)  
Two methods of interval test of quantitative trait loci (QTLs) based on trait-ma rker regression are proposed, named as TMRIT-I and TMRIT-II, respectively. The f ormer uses likelihood ratio statistic for significance test, equivalent to the m ethod of simplified composite interval mapping (sCIM) based on least squares, bu t much simpler and quicker in calculation. The latter uses a ‘pseudo-likelihood ratio’ statistic for significance test, not only simplifying calculation furth er, but also significantly increasing statistical power. For both methods, signi ficance threshold can be estimated by permutation tests. A simulated example is given.
【Fund】: 国家自然科学基金重大项目资助!(资助号39893350)
【CateGory Index】: Q348
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