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《Hereditas(Beijing)》 2001-02
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RNA Interference and Gene Silencing

TANG Fu-chou,XUE You-fang (College of Life Sciences,Peking University,Beijing 100871, China)  
The mechanism of a new phenomenon──genetic interference directed by double-str an ded RNA was first discovered in 1998 by Andrew Fire and Craig Mello. It degrade s mRNA specifically and potently through the mediation of corresponding double-s tranded RNA and leads to post-transcriptional gene silencing. Consequently RNA i nterference was observed is eukaryotic organisms including fungi, Arabidopsis, C. elegans, trypanosomes, hydra, planaria, Drosophila, zabrafish, and mouse. M ore and more evidence supports that RNAi,co-suppression in plants, and quelling in fungi shares the same basic molecular mechanism. It indicates that this mecha nism was acquired during early evolution. RNAi plays important roles in resistan ce to virus invasion, and inhibition of transportable elements. And it is very l ikely that RNAi is also important during the normal development and regulation o f gene expression.
【Fund】: 国家自然科学基金!(39730250)资助
【CateGory Index】: Q786
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